Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | DPYD | Q12882 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1918404 | 0.84 | ATAD2 (0.52) | MEN1KMT2AALDH1A1ATAD2DPYD | |
| SCHEMBL28742651 | 0.73 | CYP1A2 (0.33) | MEN1KMT2AALDH1A1CYP1A2LMNA | |
| SCHEMBL887700 | 0.70 | ATAD2 (0.48) | MEN1KMT2AALDH1A1ATAD2DPYD | |
| SCHEMBL8933555 | 0.70 | GAA (0.48) | MEN1KMT2AALDH1A1ATAD2DPYD | |
| SCHEMBL5801051 | 0.69 | MEN1 (0.51) | MEN1KMT2AALDH1A1ATAD2DPYD | |
| SCHEMBL28229390 | 0.69 | GPR84 (0.53) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL19403692 | 0.68 | HCAR2 (0.49) | MEN1KMT2AALDH1A1ATAD2DPYD | |
| SCHEMBL22017500 | 0.67 | ATAD2 (0.45) | MEN1KMT2AALDH1A1ATAD2DPYD | |
| SCHEMBL17060272 | 0.67 | ATAD2 (0.45) | MEN1KMT2AALDH1A1ATAD2DPYD | |
| SCHEMBL7255538 | 0.67 | ATAD2 (0.45) | MEN1KMT2AALDH1A1ATAD2DPYD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169310-A1 | PROCESS FOR PREPARING MKC-442 | Triangle Pharmaceuticals Inc. (US) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000061566-A1 | PROCESS FOR PREPARING MKC-442 | TRIANGLE PHARMACEUTICALS, INC. (US) | 2000-10-19 | — | — | WO | disclosed |