Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CFD | P00746 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7522610 | 0.90 | PTGS2 (0.37) | PTGS2NR1H4NPC1LMNAPKM | |
| SCHEMBL7525030 | 0.86 | PTGS2 (0.32) | PTGS2NR1H4NPC1LMNAPKM | |
| SCHEMBL7515293 | 0.78 | PTGS2 (0.38) | PTGS2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7529855 | 0.78 | PTGS2 (0.40) | PTGS2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7522271 | 0.77 | PTGS2 (0.43) | PTGS2 | |
| SCHEMBL7524510 | 0.76 | ALOX15 (0.48) | PTGS2KDM4EALDH1A1HPGDCYP2C19 | |
| SCHEMBL7517750 | 0.75 | KDM4E (0.33) | NR1H4KDM4EUSP2ALDH1A1HPGD | |
| SCHEMBL7519659 | 0.74 | ALOX15 (0.35) | — | |
| SCHEMBL7515913 | 0.70 | VCAM1 (0.43) | — | |
| SCHEMBL7526616 | 0.69 | VCAM1 (0.38) | PTGS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |