Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7523709 | 0.81 | TOP2A (0.38) | KDM4ENPC1KMT2A | |
| SCHEMBL7525879 | 0.80 | POLB (0.32) | — | |
| SCHEMBL4670913 | 0.79 | HTT (0.33) | HTTSMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL8140932 | 0.77 | HIF1A (0.30) | — | |
| SCHEMBL7119512 | 0.75 | KDM1A (0.39) | HTTSMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL29808393 | 0.74 | KDM4E (0.31) | HTTSMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL20565609 | 0.74 | KDM4E (0.31) | HTTSMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL4670884 | 0.74 | KDM1A (0.35) | HTTSMN1; SMN2KDM4EMEN1ALDH1A1 | |
| SCHEMBL7263829 | 0.74 | SIRT2 (0.38) | HTTSMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL4253743 | 0.74 | APP (0.37) | HTTSMN1; SMN2KDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037885-B1 | NOVEL WATER SOLUBLE PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2002-03-27 | — | — | EP | claimed |
| US-5879592-A | Water soluble photochromic compounds, compositions and optical elements comprising the compounds | PPG INDUSTRIES, INC. (US) | 1999-03-09 | — | — | US | claimed |
| EP-1037885-B1 | NOVEL WATER SOLUBLE PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2002-03-27 | — | — | EP | disclosed |
| US-5879592-A | Water soluble photochromic compounds, compositions and optical elements comprising the compounds | PPG INDUSTRIES, INC. (US) | 1999-03-09 | — | — | US | disclosed |