Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.52 |
| ▸ | TRHR | P34981 | 1/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.47 |
| ▸ | REN | P00797 | 1/20 | 0.47 |
| ▸ | PREP | P48147 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7271897 | 0.92 | ACE (0.53) | ACEDPP4DPP8RENPREP | |
| SCHEMBL11333608 | 0.90 | ACE (0.45) | ACETRHRREN | |
| SCHEMBL11332063 | 0.90 | ACE (0.45) | ACETRHRREN | |
| SCHEMBL11791864 | 0.89 | ACE (0.49) | ACETRHRDPP4DPP8REN | |
| SCHEMBL7273181 | 0.89 | ACE (0.50) | ACEDPP4DPP8RENPREP | |
| SCHEMBL7264396 | 0.89 | KDM4E (0.51) | ACEDPP4DPP8RENPREP | |
| SCHEMBL11585814 | 0.89 | ACE (0.49) | ACETRHRDPP4DPP8REN | |
| SCHEMBL8265844 | 0.88 | ACE (0.65) | ACEDPP4DPP8RENPREP | |
| SCHEMBL8257846 | 0.88 | ACE (0.65) | ACEDPP4DPP8RENPREP | |
| SCHEMBL13533686 | 0.88 | ACE (0.65) | ACEDPP4DPP8RENPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002001956-A1 | HISTIDYL-PROLINE DIKETOPIPERAZINE AND METHOD OF USE | PRASAD CHANDAN (US) | 2002-01-10 | — | — | WO | disclosed |
| US-6090780-A | ADMINISTERING TO THE PATIENT SUFFERING FROM ALCOHOL ADDITION HISTIDYL-PROLINE DIKETOPIPERZINE OR STERIOISOMER TO ATTENUATE THE DESIRE OF ALCOHOL WITHOUT SUPPRESSING THE APPETITE | CHANDON PRASAD (US) | 2000-07-18 | — | — | US | disclosed |
| US-5418218-A | Histidyl-proline diketopiperazine (cyclo his-pro) a cns-active pharmacologic agent | THE UNIVERSITY OF MARYLAND AT BALTIMORE (US) | 1995-05-23 | — | — | US | disclosed |
| US-4045556-A | ANTIDEPRESSANTS, PYSCHOSTIMULANTS; SILYLATION | SCHWERTNER EBERHARD | 1977-08-30 | — | — | US | disclosed |