Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6676515 | 0.87 | SCN2A (0.43) | ALDH1A1ALOX15CYP2C9LMNATYR | |
| SCHEMBL7521592 | 0.82 | ALOX15 (0.39) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL8377972 | 0.81 | — | — | |
| SCHEMBL7527865 | 0.78 | TRPA1 (0.35) | ALDH1A1ALOX15CYP2C9TRPA1ATM | |
| SCHEMBL5692376 | 0.76 | PTGS1 (0.42) | ALDH1A1ALOX15TRPA1ATMMAPK1 | |
| SCHEMBL7515890 | 0.76 | ALDH1A1 (0.41) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL7525374 | 0.76 | ALDH1A1 (0.36) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL7705080 | 0.75 | ALDH1A1 (0.43) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL7199857 | 0.73 | ALDH1A1 (0.59) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL9223934 | 0.73 | POLB (0.42) | ALDH1A1ALOX15HSD17B10ATMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |