Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7524517 | 0.87 | ALDH1A1 (0.37) | SCN2AGABRA1GABRB2GAAALDH1A1 | |
| SCHEMBL5692376 | 0.84 | PTGS1 (0.42) | GAAALDH1A1CA2MAPK1KDM4E | |
| SCHEMBL5692161 | 0.82 | CA2 (0.43) | SCN2AGABRA1GABRB2GAAALDH1A1 | |
| SCHEMBL9007326 | 0.80 | SCN2A (0.31) | SCN2A | |
| SCHEMBL7521592 | 0.79 | ALOX15 (0.39) | SCN2AGABRA1GABRB2GAAALDH1A1 | |
| SCHEMBL5692101 | 0.78 | ALOX5 (0.34) | GABRA1GABRB2ALDH1A1ATM | |
| SCHEMBL5692018 | 0.78 | GABRA1 (0.39) | GABRA1GABRB2ALDH1A1TSHRLMNA | |
| SCHEMBL7523209 | 0.77 | GABRA1 (0.41) | SCN2AGABRA1GABRB2GAAALDH1A1 | |
| SCHEMBL7519263 | 0.77 | SCN2A (0.43) | SCN2AGABRA1GABRB2GAAALDH1A1 | |
| SCHEMBL7527865 | 0.77 | TRPA1 (0.35) | GABRA1GABRB2ALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1468692-A2 | Use of 2,6-di-alkyl-4-silyl-phenols for treating xanthoma | MERRELL PHARMACEUTICALS INC. (US) | 2004-10-20 | — | — | EP | disclosed |
| US-5532400-A | 2,6-di-alkyl-4-silyl-phenols as antiatheroscelerotic agents | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-02 | — | — | US | disclosed |
| EP-0464852-B1 | Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents and as antioxidants | MERRELL DOW PHARMA (US) | 1996-03-20 | — | — | EP | disclosed |
| US-5155250-A | 2,6-DI-ALKYL-4-SILYL-PHENOLS AS ANTIATHEROSCEROTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0464852-A1 | Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents and as antioxidants | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-08 | — | — | EP | disclosed |