SCHEMBL752453

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL753107	0.83	GRM2 (0.41)	HTR2AKCNH2GRM2TAAR1HTR2C
	SCHEMBL20261121	0.83	CYP1A2 (0.48)	KCNH2GRM2TAAR1
	SCHEMBL19441154	0.82	GRM2 (0.33)	GRM2
	SCHEMBL18633321	0.79	GRM2 (0.34)	HTR2AKCNH2GRM2TAAR1PDGFRB
	SCHEMBL19387244	0.77	TSHR (0.49)	HTR2AGRM2HTR2CDRD2HTR7
	SCHEMBL7437052	0.76	TAAR1 (0.68)	PTGS1PTGS2TAAR1AOC3MAOB
	SCHEMBL13808352	0.75	ACHE (0.68)	KCNH2PTGS1PTGS2TAAR1AOC3
	SCHEMBL757316	0.75	MAOB (0.53)	MAOB
	SCHEMBL20733046	0.73	GRM2 (0.38)	PTGS1PTGS2GRM2HTT
	SCHEMBL23641150	0.73	DHFR (0.41)	HTR2AKCNH2GRM2TAAR1HTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.