SCHEMBL7524798

SCHEMBL7524798

[CH2]c1ccccc1Sc1ccc(Cl)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.53
KMT2A Q03164 4/20 0.53
SLC6A4 P31645 1/20 0.50
L3MBTL1 Q9Y468 3/20 0.48
CYP1A2 P05177 3/20 0.46
CYP3A4 P08684 3/20 0.46
CYP2D6 P10635 3/20 0.46
HTR1A P08908 2/20 0.46
CYP2C9 P11712 2/20 0.46
HTR3A P46098 2/20 0.46
RHEB Q15382 2/20 0.46
LMNA P02545 3/20 0.45
ALDH1A1 P00352 2/20 0.45
NPSR1 Q6W5P4 2/20 0.45
BLM P54132 1/20 0.45
NOD2 Q9HC29 1/20 0.45
HDAC1 Q13547 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
DHFR P00374 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2944523 0.82 SIRT1 (0.45) MEN1KMT2AL3MBTL1HTR1AHTR3A
SCHEMBL2154400 0.79 HTR1A (0.45) MEN1KMT2ASLC6A4L3MBTL1CYP1A2
SCHEMBL8433301 0.78 MEN1 (0.57) MEN1KMT2ASLC6A4L3MBTL1CYP1A2
SCHEMBL30958573 0.78 SLC6A4 (0.53) MEN1KMT2ASLC6A4L3MBTL1CYP1A2
SCHEMBL3547807 0.75 SLC6A4 (0.50) MEN1KMT2ASLC6A4L3MBTL1CYP1A2
SCHEMBL14388103 0.75 SLC6A4 (0.54) MEN1KMT2ASLC6A4L3MBTL1CYP1A2
SCHEMBL1713296 0.75 CYP1A2 (0.53) MEN1KMT2ASLC6A4L3MBTL1CYP1A2
SCHEMBL31016398 0.75 CYP1A2 (0.53) MEN1KMT2ASLC6A4L3MBTL1CYP1A2
SCHEMBL28853123 0.75 HDAC1 (0.54) MEN1KMT2ASLC6A4L3MBTL1CYP1A2
SCHEMBL11148598 0.74 RHEB (0.46) KMT2AL3MBTL1RHEBLMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1189891-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION Bioscience AG (DE) 2002-03-27 EP claimed
US-6362342-B1 BIOSYNTHESIS; DRUG LIBRARIES LION BIOSCIENCE AG (DE) 2002-03-26 US claimed
WO-2001000594-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2001-01-04 WO claimed
CN-106008571-A Boron-containing small molecules 安纳考尔医药公司 2016-10-12 CN disclosed
CN-106008583-A BORON-CONTAINING SMALL MOLECULES 安纳考尔医药公司 2016-10-12 CN disclosed
CN-105949230-A BORON-CONTAINING SMALL MOLECULES 安纳考尔医药公司 2016-09-21 CN disclosed
CN-102532180-B The little molecule of boracic 安纳考尔医药公司 2016-06-29 CN disclosed
EP-1189891-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION Bioscience AG (DE) 2002-03-27 EP disclosed
US-6362342-B1 BIOSYNTHESIS; DRUG LIBRARIES LION BIOSCIENCE AG (DE) 2002-03-26 US disclosed
WO-2001000594-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2001-01-04 WO disclosed