Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | IGFBP3 | P17936 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | IGFBP5 | P24593 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9768818 | 0.88 | DHODH (0.47) | KDM4ETSHRALDH1A1HSD17B10KMT2A | |
| SCHEMBL9398456 | 0.86 | GRM2 (0.46) | DHODHPARP1NQO2 | |
| SCHEMBL2908140 | 0.85 | KDM4E (0.46) | KDM4ETSHRALDH1A1HSD17B10KMT2A | |
| SCHEMBL11668909 | 0.84 | ALDH1A1 (0.47) | KDM4ETSHRALDH1A1HSD17B10KMT2A | |
| SCHEMBL9441962 | 0.83 | DHODH (0.43) | KDM4ETSHRALDH1A1HSD17B10KMT2A | |
| SCHEMBL29384232 | 0.82 | IGFBP3 (0.41) | TSHRKMT2AMEN1IGFBP3MGAM | |
| SCHEMBL158714 | 0.82 | IGFBP3 (0.41) | TSHRKMT2AMEN1IGFBP3MGAM | |
| SCHEMBL9379118 | 0.82 | NQO2 (0.51) | KDM4ETSHRALDH1A1HSD17B10HPGD | |
| SCHEMBL3328166 | 0.81 | MGAM (0.42) | KDM4ETSHRALDH1A1HSD17B10KMT2A | |
| SCHEMBL2910010 | 0.81 | MGAM (0.42) | KDM4ETSHRALDH1A1HSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465653-B2 | HEATING AND HYDROLYZING/DECARBOXYLATING 4-HYDROXYQUINOLINE CARBOXYLIC ACID ESTER IN PRESENCE OF WATER IN LIQUID OR VAPOR PHASE; PLANT SAFENING AGENTS | RHODIA CHIMIE (FR) | 2002-10-15 | — | — | US | claimed |
| US-20020007067-A1 | Noncatalyzed synthesis of 4-hydroxyquinolines and/or tautomers thereof | RHODIA CHIMIE (FR) | 2002-01-17 | — | — | US | claimed |
| US-6465653-B2 | HEATING AND HYDROLYZING/DECARBOXYLATING 4-HYDROXYQUINOLINE CARBOXYLIC ACID ESTER IN PRESENCE OF WATER IN LIQUID OR VAPOR PHASE; PLANT SAFENING AGENTS | RHODIA CHIMIE (FR) | 2002-10-15 | — | — | US | disclosed |
| US-20020007067-A1 | Noncatalyzed synthesis of 4-hydroxyquinolines and/or tautomers thereof | RHODIA CHIMIE (FR) | 2002-01-17 | — | — | US | disclosed |
| US-5344922-A | 4-hydroxyquinaldic acid derivatives | BOARD OF REGENTS, UNIVERSITY OF TEXAS | 1994-09-06 | — | — | US | disclosed |
| US-5028707-A | 4-hydroxyquinaldic acid derivatives | BOARD OF REGENTS, UNIVERSITY OF TEXAS (US) | 1991-07-02 | — | — | US | disclosed |
| WO-1991007390-A1 | 4-HYDROXYQUINALDIC ACID DERIVATIVES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1991-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020007067-A1 | Noncatalyzed synthesis of 4-hydroxyquinolines and/or tautomers thereof | HAAO, HPD, HAO2 | KDM4E 868/4885TSHR 4505/4885ALDH1A1 619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.