Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 3/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.48 |
| ▸ | PRKCB | P05771 | 2/20 | 0.45 |
| ▸ | PRKCH | P24723 | 2/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | WEE1 | P30291 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15797114 | 0.85 | PRKCB (0.54) | PRKCAGSK3BCAMK2DPRKCBPRKCH | |
| SCHEMBL19217082 | 0.85 | CAMK2D (0.46) | PRKCAGSK3BCAMK2DPRKCBPRKCH | |
| SCHEMBL5686050 | 0.84 | CAMK2D (0.57) | PRKCAGSK3BCAMK2DPRKCBPRKCH | |
| SCHEMBL20243386 | 0.83 | CAMK2D (0.55) | PRKCACAMK2DPRKCBPRKCHPRKCE | |
| SCHEMBL15797184 | 0.81 | PDE9A (0.49) | PRKCAGSK3BCAMK2DPRKCBPRKCH | |
| SCHEMBL8317513 | 0.79 | CAMK2D (0.50) | PRKCAGSK3BCAMK2DPRKCBPRKCH | |
| SCHEMBL19217027 | 0.78 | IMPDH2 (0.67) | PRKCACAMK2DPRKCBPRKCHPRKCE | |
| SCHEMBL19217028 | 0.78 | GSK3B (0.51) | PRKCAGSK3BCAMK2DPRKCBPRKCH | |
| SCHEMBL22592333 | 0.76 | PDE9A (0.51) | PRKCAGSK3BCAMK2DPRKCBPRKCH | |
| SCHEMBL19216926 | 0.76 | PRKCB (0.48) | PRKCACAMK2DPRKCBPRKCHPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020188018-A1 | 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta | GONG LEYI (US) | 2002-12-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020188018-A1 | 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta | GSK3B, GSK3A, PYGL | PRKCA 62/4885GSK3B 1/4885CAMK2D 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.