Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.63 |
| ▸ | CES1 | P23141 | 2/20 | 0.59 |
| ▸ | MAOA | P21397 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187096 | 0.81 | MAOA (0.53) | AKR1B1CES1MAOATDP1L3MBTL1 | |
| SCHEMBL29555172 | 0.81 | MAOA (0.53) | AKR1B1CES1MAOATDP1L3MBTL1 | |
| SCHEMBL44496 | 0.80 | CES1 (0.90) | AKR1B1CES1MAOATDP1L3MBTL1 | |
| SCHEMBL29408351 | 0.80 | CES1 (0.90) | AKR1B1CES1MAOATDP1L3MBTL1 | |
| SCHEMBL29437756 | 0.80 | CES1 (0.90) | AKR1B1CES1MAOATDP1L3MBTL1 | |
| SCHEMBL7055100 | 0.76 | CES1 (0.60) | AKR1B1CES1MAOATDP1L3MBTL1 | |
| SCHEMBL13712393 | 0.76 | CES1 (1.00) | CES1MAOATDP1L3MBTL1ALDH1A1 | |
| SCHEMBL9642938 | 0.75 | CES1 (0.59) | AKR1B1CES1MAOATDP1L3MBTL1 | |
| SCHEMBL4221971 | 0.75 | CES1 (0.59) | AKR1B1CES1MAOATDP1L3MBTL1 | |
| SCHEMBL4175611 | 0.75 | CES1 (0.59) | AKR1B1CES1MAOATDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189887-A2 | PROCESS FOR PREPARING 10,11-METHANOBENZOSUBERANE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-03-27 | — | — | EP | claimed |
| WO-2000075121-A2 | PROCESS FOR PREPARING 10,11-METHANOBENZOSUBERANE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2000-12-14 | — | — | WO | claimed |
| EP-1189887-A2 | PROCESS FOR PREPARING 10,11-METHANOBENZOSUBERANE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000075121-A2 | PROCESS FOR PREPARING 10,11-METHANOBENZOSUBERANE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2000-12-14 | — | — | WO | disclosed |