Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | LTA4H | P09960 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | EP300 | Q09472 | 1/20 | 0.47 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.47 |
| ▸ | NQO1 | P15559 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9393621 | 0.89 | TSHR (0.55) | ALDH1A1MAPK1HTTL3MBTL1LTA4H | |
| SCHEMBL21933156 | 0.87 | ALDH1A1 (0.64) | ALDH1A1MAPK1HTTL3MBTL1LTA4H | |
| SCHEMBL19612223 | 0.86 | ALDH1A1 (0.48) | ALDH1A1MAPK1HTTL3MBTL1LTA4H | |
| SCHEMBL791852 | 0.82 | HTT (0.86) | ALDH1A1MAPK1HTTL3MBTL1LTA4H | |
| SCHEMBL536544 | 0.82 | LTA4H (0.58) | LTA4HTTRTSHRMAPT | |
| SCHEMBL31116611 | 0.82 | CA1 (0.61) | ALDH1A1MAPK1HTTL3MBTL1IDO1 | |
| SCHEMBL357145 | 0.82 | CA1 (0.61) | ALDH1A1MAPK1HTTL3MBTL1IDO1 | |
| SCHEMBL16920407 | 0.82 | CYP1A2 (0.52) | ALDH1A1MAPK1HTTL3MBTL1LTA4H | |
| SCHEMBL31666411 | 0.80 | IDO1 (0.64) | ALDH1A1MAPK1HTTL3MBTL1IDO1 | |
| SCHEMBL17970735 | 0.79 | ALDH1A1 (0.59) | ALDH1A1MAPK1HTTL3MBTL1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779273-B1 | Naphthyl glyoxamides as sPLA2 inhibitors | LILLY CO ELI (US) | 2002-03-20 | — | — | EP | disclosed |
| US-6090850-A | SEPSIS SHOCK | ELI LILLY AND COMPANY (US) | 2000-07-18 | — | — | US | disclosed |
| WO-1997021716-A1 | NAPHTHYL GLYOXAMIDES AS sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-06-19 | — | — | WO | disclosed |
| EP-0779273-A1 | Naphthyl glyoxamides as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1997-06-18 | — | — | EP | disclosed |