SCHEMBL7526384

SCHEMBL7526384

CC(=O)Oc1c(C(C)(C)C)cc(O)c(CNC(=O)CCl)c1C(C)(C)C

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.34
SMN1; SMN2 Q16637 4/20 0.34
HTT P42858 3/20 0.34
VCAM1 P19320 2/20 0.32
GAA P10253 1/20 0.32
KMT2A Q03164 1/20 0.32
LMNA P02545 2/20 0.31
EGFR P00533 1/20 0.31
KDM4E B2RXH2 2/20 0.30
CYP1A2 P05177 1/20 0.30
MAPT P10636 1/20 0.30
ALOX15 P16050 1/20 0.30
ATP2A2 P16615 1/20 0.30
ATP2A3 Q93084 1/20 0.30
NPC1 O15118 1/20 0.30
MITF O75030 1/20 0.30
THRB P10828 1/20 0.30
MAPK1 P28482 1/20 0.30
RAB9A P51151 1/20 0.30
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7523149 0.79 KDM4E (0.35) ALDH1A1SMN1; SMN2HTTVCAM1GAA
SCHEMBL7524587 0.77 VCAM1 (0.33) ALDH1A1SMN1; SMN2HTTVCAM1GAA
SCHEMBL7520741 0.76 KDM4E (0.39) ALDH1A1SMN1; SMN2HTTVCAM1GAA
SCHEMBL3622229 0.74 NR5A2 (0.42) ALDH1A1SMN1; SMN2HTTGAAKMT2A
SCHEMBL3622724 0.74 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2HTTGAAKMT2A
SCHEMBL8368654 0.73 KDM4E (0.40) ALDH1A1SMN1; SMN2HTTVCAM1GAA
SCHEMBL27373776 0.72 VCAM1 (0.33) VCAM1
SCHEMBL3617041 0.70 ESRRG (0.38) ALDH1A1SMN1; SMN2HTTLMNAEGFR
SCHEMBL6307528 0.70 MAPT (0.36) ALDH1A1SMN1; SMN2HTTVCAM1GAA
SCHEMBL7526381 0.69 NR1H4 (0.34) ALDH1A1SMN1; SMN2HTTVCAM1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0791589-B1 4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENES WHICH INHIBIT LDL OXIDATION CHUGAI PHARMACEUTICAL CO LTD (JP) 2002-03-06 EP disclosed
EP-0665208-B1 4-ALKOXY-2,6-DI-t-BUTYLPHENOL DERIVATIVE CHUGAI PHARMACEUTICAL CO LTD (JP) 1999-01-13 EP disclosed
US-5789436-A ARTERIOSCLEROSIS; INHIBITORS OF OXIDATION OF LOW DENSITY LIPOPROTEINS; CHUGAI SEIYAK KABUSHIKI KAISHA (JP) 1998-08-04 US disclosed
US-5663373-A ANTIISCHEMIC AGENTS AND ANTIOXIDANTS FORMED IN MULTISTAGE REACTION WITH GRIGNARD REAGENT WITH ALDEHYDE, DISSOLVING, ACIDIFICATION, DEPROTECTION AND CYCLIZATION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1997-09-02 US disclosed
EP-0791589-A1 4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENES WHICH INHIBIT LDL OXIDATION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1997-08-27 EP disclosed
US-5606089-A ANTIISCHEMIC AGENTS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1997-02-25 US disclosed
US-5574178-A CHEMICAL INTERMEDIATES FOR OXIDATION RESISTANCE AND ANTIISCHEMIC AGENTS FORMED BY MULTISTAGE CYCLIZATION OF ALDEHYDE-ALCOHOL CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1996-11-12 US disclosed
EP-0665208-A1 4-ALKOXY-2,6-DI-t-BUTYLPHENOL DERIVATIVE Chugai Seiyaku Kabushiki Kaisha (JP) 1995-08-02 EP disclosed