Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 8/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.45 |
| ▸ | WNT3A | P56704 | 3/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649870 | 0.91 | MTNR1A (0.71) | MTNR1AKDM4EROCK2ROCK1CYP3A4 | |
| SCHEMBL7523264 | 0.89 | MTNR1A (0.71) | MTNR1AKDM4EROCK2ROCK1CYP3A4 | |
| SCHEMBL166877 | 0.89 | KDM4C (0.51) | MTNR1AKDM4EPTGER1PTGER4PTGER3 | |
| SCHEMBL3639598 | 0.83 | MTNR1A (0.59) | MTNR1AKDM4EROCK2ROCK1CYP3A4 | |
| SCHEMBL7526482 | 0.82 | MTNR1A (0.85) | MTNR1AROCK2ROCK1CYP3A4CYP2D6 | |
| SCHEMBL8481900 | 0.80 | MTNR1A (0.57) | MTNR1ACTNNB1WNT3APKM | |
| SCHEMBL3366209 | 0.80 | MTNR1A (0.59) | MTNR1AKDM4EROCK2ROCK1CYP3A4 | |
| SCHEMBL8946082 | 0.80 | PTGER1 (0.46) | MTNR1APTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8488569 | 0.78 | MTNR1A (0.55) | MTNR1AKDM4EROCK2ROCK1CYP3A4 | |
| SCHEMBL7268290 | 0.77 | MTNR1A (0.56) | MTNR1AKDM4EROCK2ROCK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8487121-B2 | Chromane derivatives as TRPV3 modulators | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-07-16 | — | — | US | disclosed |
| US-20100311778-A1 | CHROMANE DERIVATIVES AS TRPV3 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-12-09 | — | — | US | disclosed |
| EP-2254879-A2 | CHROMANE DERIVATIVES AS TRPV3 MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2010-12-01 | — | — | EP | disclosed |
| US-7572809-B2 | Isoquinoline aminopyrazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-08-11 | — | — | US | disclosed |
| US-7572809-B2 | Isoquinoline aminopyrazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-08-11 | — | — | US | disclosed |
| US-7572809-B2 | Isoquinoline aminopyrazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-08-11 | — | — | US | disclosed |
| WO-2009084034-A2 | CHROMANE DERIVATIVES AS TRPV3 MODULATORS | GLENMARK PHARMACEUTICALS, S. A. (CH) | 2009-07-09 | — | — | WO | disclosed |
| CN-101341145-A | Isoquinoline aminopyrazole derivatives, their manufacture and use as pharmaceutical agents for the treatment of cancer | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | CN | disclosed |
| EP-1966190-A1 | ISOQUINOLINE AMINOPYRAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2008-09-10 | — | — | EP | disclosed |
| US-20070179151-A1 | Isoquinoline aminopyrazole derivatives | F. HOFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | US | disclosed |
| US-6492374-B2 | AN ALKYL AMINE SUBSTITUTED ISOBENZOFURAN COMPOUND USEFUL FOR CERTAIN PSYCHIATRIC AND NEUROLOGICAL DISORDERS; POTENTLY BINDING TO THE 5-HT1A RECEPTOR | H. LUNDBECK A/S (DK) | 2002-12-10 | — | — | US | disclosed |
| EP-1246820-A1 | NOVEL HETEROARYL DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2002-10-09 | — | — | EP | disclosed |
| US-20020032205-A1 | Benzofuran derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2002-03-14 | — | — | US | disclosed |
| EP-0873993-B1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-02-20 | — | — | EP | disclosed |
| CN-1329605-A | Benzofuran derivatives their preparation and use | LUNDBECK & CO AS H (DK) | 2002-01-02 | — | — | CN | disclosed |
| EP-1137644-A1 | BENZOFURAN DERIVATIVES, THEIR PREPARATION AND USE | H. Lundbeck A/S (DK) | 2001-10-04 | — | — | EP | disclosed |
| WO-2001049683-A1 | NOVEL HETEROARYL DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2001-07-12 | — | — | WO | disclosed |
| WO-2000034263-A1 | BENZOFURAN DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2000-06-15 | — | — | WO | disclosed |
| US-5919814-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 1999-07-06 | — | — | US | disclosed |
| EP-0873993-A1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-10-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179151-A1 | Isoquinoline aminopyrazole derivatives | CYP3A5, CYP3A43, CYP3A4 | MTNR1A 3030/4885KDM4E 2767/4885ROCK2 3461/4885 |
| US-20100311778-A1 | CHROMANE DERIVATIVES AS TRPV3 MODULATORS | TRPV3, TRPV2, TRPV1 | MTNR1A 187/4885KDM4E 3601/4885ROCK2 2449/4885 |
| US-20020032205-A1 | Benzofuran derivatives, their preparation and use | HTR1F, HTR1A, HTR1D | MTNR1A 427/4885KDM4E 2874/4885ROCK2 4078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.