SCHEMBL7526792

SCHEMBL7526792

O=[C]Nc1c(F)cccc1C(F)(F)F

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 2/20 0.44
SLC22A12 Q96S37 3/20 0.38
JAK2 O60674 1/20 0.34
KAT6A Q92794 1/20 0.33
LMNA P02545 1/20 0.33
GAA P10253 1/20 0.33
ALDH1A1 P00352 3/20 0.33
HSD11B1 P28845 1/20 0.33
KMT2A Q03164 1/20 0.33
POLB P06746 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
PTGES2 Q9H7Z7 1/20 0.32
KCNN4 O15554 2/20 0.32
CES1 P23141 1/20 0.32
STIM1 Q13586 1/20 0.32
ORAI1 Q96D31 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL423086 0.82 KMT2A (0.39) GAAALDH1A1KMT2ACES1
SCHEMBL883519 0.75 PTGS2 (0.44) PTGS2SLC22A12JAK2KAT6AALDH1A1
SCHEMBL7526797 0.74 PTGS2 (0.44) PTGS2SLC22A12JAK2KAT6ALMNA
SCHEMBL7527595 0.74 EPHX2 (0.44) PTGS2SLC22A12KAT6AALDH1A1KMT2A
Hydrochloric Acid SCHEMBL2771576 0.73 ALDH1A1 (0.52) PTGS2SLC22A12JAK2KAT6AGAA
SCHEMBL14350116 0.72 PTGS2 (0.46) PTGS2SLC22A12JAK2KAT6AGAA
SCHEMBL23322563 0.71 PTGS2 (0.49) PTGS2ALDH1A1KMT2AKCNN4
SCHEMBL20560736 0.71 PTGS2 (0.49) PTGS2KAT6ALMNAGAAALDH1A1
SCHEMBL27688702 0.71 KIF11 (0.48) PTGS2SLC22A12KAT6AGAAKMT2A
SCHEMBL5022148 0.71 PTGS2 (0.49) PTGS2ALDH1A1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1189891-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION Bioscience AG (DE) 2002-03-27 EP claimed
US-6362342-B1 BIOSYNTHESIS; DRUG LIBRARIES LION BIOSCIENCE AG (DE) 2002-03-26 US claimed
WO-2001000594-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2001-01-04 WO claimed
EP-1189891-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION Bioscience AG (DE) 2002-03-27 EP disclosed
US-6362342-B1 BIOSYNTHESIS; DRUG LIBRARIES LION BIOSCIENCE AG (DE) 2002-03-26 US disclosed
WO-2001000594-A1 TRIAZOLE COMPOUNDS AND COMBINATORIAL LIBRARIES THEREOF LION BIOSCIENCE AG (DE) 2001-01-04 WO disclosed