Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 6/20 | 0.50 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | AKT2 | P31751 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756111 | 0.81 | USP7 (0.43) | USP7AKT1AKT2MAPTALDH1A1 | |
| SCHEMBL756109 | 0.73 | PIK3CD (0.41) | USP7AKT1AKT2MAPTALDH1A1 | |
| SCHEMBL7673469 | 0.72 | CDK2 (0.57) | USP7AKT1AKT2CDK2MEN1 | |
| SCHEMBL755266 | 0.70 | USP7 (0.38) | USP7AKT1AKT2MAP3K14 | |
| SCHEMBL1318629 | 0.69 | AKT1 (0.53) | USP7AKT1AKT2CDK2PIK3CA | |
| SCHEMBL30218059 | 0.69 | AKT1 (0.51) | USP7AKT1AKT2CDK2ALDH1A1 | |
| SCHEMBL7467961 | 0.66 | AKT1 (0.56) | USP7AKT1AKT2CDK2 | |
| SCHEMBL15910846 | 0.62 | MAP3K14 (0.40) | USP7AKT1AKT2CDK2ALDH1A1 | |
| SCHEMBL1016773 | 0.62 | MAPT (0.67) | MAPTALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL18745789 | 0.62 | MAPT (0.67) | MAPTALDH1A1SMN1; SMN2MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | claimed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | claimed |