Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 3/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 2/20 | 0.41 |
| ▸ | AKT2 | P31751 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL752682 | 0.81 | USP7 (0.50) | USP7PIK3CBMEN1AKT1AKT2 | |
| SCHEMBL11026812 | 0.81 | USP7 (0.60) | USP7ALDH1A1CYP1A2CYP3A4CYP2A6 | |
| SCHEMBL7683222 | 0.73 | CDK2 (0.49) | USP7AKT1AKT2 | |
| SCHEMBL756109 | 0.72 | PIK3CD (0.41) | USP7PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL14811752 | 0.71 | F12 (0.45) | PIK3CGMEN1PSIP1AXLMKNK1 | |
| SCHEMBL30218059 | 0.68 | AKT1 (0.51) | USP7PIK3CDPIK3R1AKT1AKT2 | |
| SCHEMBL1318629 | 0.68 | AKT1 (0.53) | USP7PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL12197126 | 0.67 | PIK3CD (0.60) | PIK3CDPIK3R1PIK3CBPIK3CGMEN1 | |
| SCHEMBL225149 | 0.66 | CYP2A6 (0.68) | MEN1PSIP1AXLMKNK1MKNK2 | |
| SCHEMBL18745788 | 0.66 | CYP2A6 (0.68) | MEN1PSIP1AXLMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | claimed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | claimed |