Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | AKT2 | P31751 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | CCR8 | P51685 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23550100 | 0.74 | NPC1 (0.53) | KDM4EL3MBTL1ALOX15LMNACCR1 | |
| SCHEMBL752682 | 0.73 | USP7 (0.50) | PIK3CAPIK3CBKDM4EAKT1AKT2 | |
| SCHEMBL756111 | 0.72 | USP7 (0.43) | PIK3CDPIK3R1PIK3CAPIK3CBPIK3CG | |
| SCHEMBL71031 | 0.63 | KDM4E (0.56) | PIK3CDPIK3CAPIK3CGKDM4EL3MBTL1 | |
| Dipyridyl SCHEMBL722577 | 0.63 | KDM4E (0.93) | KDM4EL3MBTL1ALOX15LMNACCR1 | |
| Dipyridyl SCHEMBL29467582 | 0.63 | KDM4E (0.93) | KDM4EL3MBTL1ALOX15LMNACCR1 | |
| Dipyridyl SCHEMBL721272 | 0.63 | KDM4E (0.93) | KDM4EL3MBTL1ALOX15LMNACCR1 | |
| Dipyridyl SCHEMBL3796795 | 0.63 | KDM4E (0.93) | KDM4EL3MBTL1ALOX15LMNACCR1 | |
| SCHEMBL25415000 | 0.62 | PTGS2 (0.59) | KDM4EL3MBTL1ALOX15LMNACCR1 | |
| Dipyridyl SCHEMBL29167113 | 0.62 | KDM4E (0.79) | KDM4EL3MBTL1ALOX15LMNACCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | claimed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | claimed |