Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 5/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7528711 | 0.83 | HSD11B1 (0.47) | HSD11B1CYP2A6PFKFB3PDE10APIK3CB | |
| SCHEMBL7524797 | 0.80 | DGAT1 (0.40) | HSD11B1CYP2A6PFKFB3BRD4 | |
| SCHEMBL27306734 | 0.76 | ESR1 (0.42) | ADRA2AADRA2BADRA2CESR1MAPT | |
| SCHEMBL24185908 | 0.73 | IDO1 (0.44) | ADRA2AADRA2BADRA2CESR1 | |
| SCHEMBL10985464 | 0.73 | ESR1 (0.44) | ADRA2AADRA2BADRA2CESR1MAPT | |
| SCHEMBL3151691 | 0.73 | ALDH1A1 (0.43) | ADRA2AADRA2BADRA2CESR1MAPT | |
| SCHEMBL15201143 | 0.73 | BRD4 (0.47) | ADRA2AADRA2BADRA2CESR1BRD4 | |
| SCHEMBL18509355 | 0.73 | ESR1 (0.55) | L3MBTL1ESR1BRD4 | |
| SCHEMBL14627758 | 0.73 | ESR1 (0.42) | ADRA2AADRA2BADRA2CL3MBTL1ESR1 | |
| SCHEMBL2793396 | 0.73 | ESR1 (0.58) | L3MBTL1ESR1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1193027-C | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 2005-03-16 | — | — | CN | disclosed |
| CN-1411457-A | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 2003-04-16 | — | — | CN | disclosed |
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| EP-0801329-B1 | RADIATION-SENSITIVE COMPOSITION AND RECORDING MEDIUM PRODUCED THEREFROM | CLARIANT FINANCE BVI LTD (VG) | 2002-03-27 | — | — | EP | disclosed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |
| US-6110639-A | Radiation-sensitive composition and recording medium using the same | HOECHST JAPAN LIMITED (JP) | 2000-08-29 | — | — | US | disclosed |
| US-5846690-A | Radiation-sensitive composition containing plasticizer | HOECHST JAPAN LIMITED (JP) | 1998-12-08 | — | — | US | disclosed |
| EP-0801329-A1 | RADIATION-SENSITIVE COMPOSITION AND RECORDING MEDIUM PRODUCED THEREFROM | HOECHST JAPAN LIMITED (JP) | 1997-10-15 | — | — | EP | disclosed |
| EP-0735422-A1 | Radiation-sensitive composition containing plasticizer | HOECHST INDUSTRY LIMITED (JP) | 1996-10-02 | — | — | EP | disclosed |
| US-5286867-A | Substituted 1-sulfonyloxy-2-pyridones and process for preparing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-02-15 | — | — | US | disclosed |
| US-5227276-A | NEGATIVE-WORKING RADIATION-SENSITIVE MIXTURE, AND RADIATION-SENSITIVE RECORDING MATERIAL PRODUCED WITH THIS MIXTURE | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-07-13 | — | — | US | disclosed |