Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | BCL2 | P10415 | 2/20 | 0.35 |
| ▸ | BECN1 | Q14457 | 2/20 | 0.35 |
| ▸ | PNMT | P11086 | 3/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7528145 | 0.81 | MAPT (0.41) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL7261773 | 0.81 | CYP11B1 (0.38) | MAPTALDH1A1HTTGAAPOLB | |
| SCHEMBL6824480 | 0.80 | KDM4E (0.38) | ALDH1A1HTTMEN1GAAKMT2A | |
| SCHEMBL6647089 | 0.77 | MIF (0.34) | — | |
| SCHEMBL4789681 | 0.76 | PNMT (0.49) | ALDH1A1LMNASLC6A3SMN1; SMN2PNMT | |
| SCHEMBL6829492 | 0.74 | F2 (0.35) | SMN1; SMN2 | |
| SCHEMBL3657554 | 0.74 | F2 (0.33) | — | |
| SCHEMBL6648198 | 0.70 | NQO2 (0.43) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7510927 | 0.69 | MIF (0.43) | SMN1; SMN2 | |
| SCHEMBL1546479 | 0.69 | LMNA (0.43) | MAPTALDH1A1LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246847-A2 | DNA ENCODING A HUMAN MELANIN CONCENTRATING HORMONE RECEPTOR (MCH1) AND USES THEREOF | Synaptic Pharmaceutical Corporation (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2002002744-A2 | DNA ENCODING A HUMAN MELANIN CONCENTRATING HORMONE RECEPTOR (MCH1) AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2002-01-10 | — | — | WO | disclosed |