Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | EP300 | Q09472 | 2/20 | 0.53 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.53 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.50 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.50 |
| ▸ | NQO1 | P15559 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30719614 | 0.98 | IDO1 (0.57) | IDO1EP300KAT8HPGDSPKM | |
| SCHEMBL1891196 | 0.98 | IDO1 (0.57) | IDO1EP300KAT8HPGDSPKM | |
| SCHEMBL5759879 | 0.84 | IDO1 (0.47) | IDO1EP300KAT8HPGDSPKM | |
| SCHEMBL29380721 | 0.83 | IDO1 (0.73) | IDO1EP300KAT8HPGDSIMPDH2 | |
| SCHEMBL419307 | 0.83 | IDO1 (0.73) | IDO1EP300KAT8HPGDSIMPDH2 | |
| SCHEMBL28007983 | 0.81 | IDO1 (0.44) | IDO1EP300KAT8HPGDSPKM | |
| SCHEMBL11068046 | 0.79 | PKM (0.52) | IDO1EP300KAT8PKMLMNA | |
| SCHEMBL9611883 | 0.78 | APP (0.46) | PKMLMNAL3MBTL1HPGDKMT2A | |
| SCHEMBL12019841 | 0.77 | IDO1 (0.64) | IDO1EP300KAT8HPGDSIMPDH2 | |
| SCHEMBL31666411 | 0.77 | IDO1 (0.64) | IDO1EP300KAT8HPGDSIMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832882-B1 | Naphthofluorene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2002-04-03 | — | — | EP | disclosed |
| US-5959103-A | Naphthofluorene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1999-09-28 | — | — | US | disclosed |
| US-5889000-A | USEFUL FOR INHIBITING BONE LOSS OR BONE RESORPTION, PARTICULARLY OSTEOPOROSIS, CARDIOVASCULAR DISORDERS, INCLUDING HYPERLIPIDEMIA AND ESTROGEN DEPENDENT CANCER | ELI LILLY AND COMPANY (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0832882-A2 | Naphthofluorene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |