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SCHEMBL7528138

SCHEMBL7528138

COc1cc(OC)c2cc(C)c3c(c2c1)OC(c1ccc(N(C)C)cc1)(c1ccc(N(C)C)cc1)C=C3

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 4/20 0.33
▸ KMT2A Q03164 4/20 0.33
▸ LMNA P02545 2/20 0.33
▸ TSHR P16473 2/20 0.33
▸ CYP2C19 P33261 2/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CALM1 P0DP23 1/20 0.32
▸ KDM4E B2RXH2 2/20 0.32
▸ HTT P42858 2/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ CYP2C9 P11712 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ HSD17B10 Q99714 1/20 0.32
▸ SLC2A1 P11166 1/20 0.32
▸ TDP1 Q9NUW8 5/20 0.31
▸ MAPK1 P28482 4/20 0.31
▸ MAPT P10636 2/20 0.31
▸ L3MBTL1 Q9Y468 2/20 0.31
▸ RXFP1 Q9HBX9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6131956 0.98 SLC2A1 (0.35) MEN1KMT2ALMNATSHRCYP2C19
SCHEMBL7525851 0.96 TDP1 (0.32) MEN1KMT2ALMNATSHRCYP2C19
SCHEMBL10106936 0.93 SLC2A1 (0.36) MEN1KMT2ALMNATSHRCYP2C19
SCHEMBL7528995 0.90 ALDH1A1 (0.37) MEN1KMT2ALMNATSHRCYP2C19
SCHEMBL10102406 0.89 SLC2A1 (0.36) MEN1KMT2ALMNATSHRCYP2C19
SCHEMBL10102270 0.88 CALM1 (0.32) MEN1KMT2ALMNATSHRCYP2C19
SCHEMBL7534540 0.86 CNR1 (0.32) LMNAKDM4EHTTALDH1A1MAPT
SCHEMBL21241905 0.85 — —
SCHEMBL10102268 0.85 SLC2A1 (0.36) MEN1KMT2ALMNATSHRCYP2C19
SCHEMBL7528300 0.85 PKM (0.37) MEN1KMT2ALMNATSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8852737-B2 Coating composition and photochromic optical article TOKUYAMA CORPORATION (JP) 2014-10-07 — — US disclosed
US-8852737-B2 Coating composition and photochromic optical article TOKUYAMA CORPORATION (JP) 2014-10-07 — — US disclosed
US-8557377-B2 Photochromic optical element TOKUYAMA CORPORATION (JP) 2013-10-15 — — US disclosed
US-8557377-B2 Photochromic optical element TOKUYAMA CORPORATION (JP) 2013-10-15 — — US disclosed
US-8409670-B2 Process for producing photochromic layered product TOKUYAMA CORPORATION (JP) 2013-04-02 — — US disclosed
US-8409670-B2 Process for producing photochromic layered product TOKUYAMA CORPORATION (JP) 2013-04-02 — — US disclosed
US-20100233485-A1 Photochromic Optical Element TOKUYAMA CORPORATION (JP) 2010-09-16 — — US disclosed
US-20100233485-A1 Photochromic Optical Element TOKUYAMA CORPORATION (JP) 2010-09-16 — — US disclosed
US-20100110521-A1 COATING COMPOSITION AND PHOTOCHROMIC OPTICAL ARTICLE TOKUYAMA CORPORATION 2010-05-06 — — US disclosed
US-20100110521-A1 COATING COMPOSITION AND PHOTOCHROMIC OPTICAL ARTICLE TOKUYAMA CORPORATION 2010-05-06 — — US disclosed
US-20070065633-A1 Process for producing photochromic layered product TOKUYAMA CORPORATION (JP) 2007-03-22 — — US disclosed
US-20070065633-A1 Process for producing photochromic layered product TOKUYAMA CORPORATION (JP) 2007-03-22 — — US disclosed
US-7169941-B2 Photochromic composition TOKUYAMA CORPORATION (JP) 2007-01-30 — — US disclosed
US-7169941-B2 Photochromic composition TOKUYAMA CORPORATION (JP) 2007-01-30 — — US disclosed
EP-0920645-B1 NAPHTHOPYRANS, COMPOSITIONS AND ARTICLES CONTAINING THEM CORNING INC (US) 2002-04-03 — — EP disclosed
US-6096246-A POLYMER LENSES WITH RADIATION RESISTANT NAPHTHOPYRAN MIXTURES CORNING INCORPORATED (US) 2000-08-01 — — US disclosed