Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | ICMT | O60725 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | KHK | P50053 | 1/20 | 0.37 |
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7528351 | 0.72 | MAPT (0.46) | ICMT | |
| Hydrochloric Acid SCHEMBL30519937 | 0.71 | HTR3A (0.50) | JAK3 | |
| SCHEMBL18509896 | 0.70 | FABP4 (0.45) | — | |
| SCHEMBL22790044 | 0.70 | NR4A2 (0.51) | APPKHK | |
| SCHEMBL18029041 | 0.70 | MAPT (0.47) | SLC6A4 | |
| SCHEMBL30958421 | 0.69 | ICMT (0.62) | ICMT | |
| SCHEMBL588980 | 0.69 | ICMT (0.62) | ICMT | |
| SCHEMBL8444605 | 0.69 | CDK2 (0.50) | ICMT | |
| Hydrochloric Acid SCHEMBL3155846 | 0.68 | ICMT (0.60) | ICMT | |
| SCHEMBL7593340 | 0.68 | MAPT (0.46) | JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |