Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | PRKDC | P78527 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7528351 | 0.89 | MAPT (0.46) | MAPTLMNAMAPK1HTTGAA | |
| SCHEMBL7591435 | 0.86 | MAPT (0.49) | MAPTLMNAMAPK1HTTHRH3 | |
| SCHEMBL18029112 | 0.82 | PTGS2 (0.50) | MAPTLMNAMAPK1HTTHRH3 | |
| Hydrochloric Acid SCHEMBL7991037 | 0.78 | HRH3 (0.40) | MAPTLMNAMAPK1HTTHRH3 | |
| SCHEMBL7976440 | 0.78 | LMNA (0.46) | MAPTLMNAMAPK1HTTNPC1 | |
| SCHEMBL7591001 | 0.76 | PRKDC (0.47) | MAPTLMNAMAPK1PRKDCNPC1 | |
| SCHEMBL20119973 | 0.75 | LMNA (0.43) | MAPTLMNAMAPK1HTTPRKDC | |
| SCHEMBL7524516 | 0.75 | MAPT (0.44) | MAPTLMNAMAPK1HTTNPC1 | |
| SCHEMBL7526498 | 0.73 | CYP3A4 (0.42) | MAPTLMNAHTTKDM4EALDH1A1 | |
| SCHEMBL19871247 | 0.73 | PTGS2 (0.48) | MAPTLMNAMAPK1HTTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |