Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7535651 | 0.96 | HTR1A (0.41) | HTR1AKCNH2HTR3EHTR3BHTR3A | |
| SCHEMBL6884875 | 0.79 | NPC1 (0.58) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7534372 | 0.79 | BCHE (0.58) | KCNH2HTR3ARAB9A | |
| SCHEMBL7222269 | 0.75 | HTR3A (0.63) | HTR3ANPC1RAB9AHDAC6KIT | |
| SCHEMBL2097950 | 0.70 | DRD2 (0.61) | HTR1AKCNH2SLC6A4 | |
| SCHEMBL7221794 | 0.70 | PRCP (0.38) | KCNH2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL3203149 | 0.70 | BCHE (0.57) | KCNH2HTR3ARAB9A | |
| SCHEMBL2090615 | 0.69 | DRD2 (0.59) | HTR1AKCNH2SLC6A4 | |
| SCHEMBL2090246 | 0.69 | KCNH2 (0.56) | HTR1AKCNH2 | |
| SCHEMBL14046593 | 0.69 | NPC1 (0.70) | HTR3ANPC1RAB9AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222185-A1 | TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2002-07-17 | — | — | EP | claimed |
| WO-2001029029-A1 | TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-04-26 | — | — | WO | claimed |
| EP-1222185-A1 | TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001029029-A1 | TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-04-26 | — | — | WO | disclosed |