Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | HTR3A | P46098 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.53 |
| ▸ | SORD | Q00796 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 4/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3203149 | 0.85 | BCHE (0.57) | BCHEACHEHTR3ATP53MAPT | |
| SCHEMBL7535651 | 0.82 | HTR1A (0.41) | BCHEACHEHTR3ARAB9ADRD4 | |
| SCHEMBL3203133 | 0.82 | DRD2 (0.55) | BCHEACHEHTR3ATP53MAPT | |
| SCHEMBL10247572 | 0.80 | ACHE (0.65) | BCHEACHEHTR3ATP53MAPT | |
| SCHEMBL7841229 | 0.80 | BCHE (0.57) | BCHEACHEHTR3ATP53MAPT | |
| Hydrochloric Acid SCHEMBL7215392 | 0.79 | BCHE (0.56) | BCHEACHEHTR3ATP53MAPT | |
| SCHEMBL7529602 | 0.79 | HTR1A (0.42) | HTR3ARAB9AKCNH2 | |
| SCHEMBL5309716 | 0.78 | BCHE (0.71) | BCHEACHEHTR3ATP53MAPT | |
| SCHEMBL4436381 | 0.78 | BCHE (0.61) | BCHEACHEHTR3ATP53MAPT | |
| Hydrochloric Acid SCHEMBL1775985 | 0.78 | ACHE (0.61) | BCHEACHEHTR3ATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222185-A1 | TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2002-07-17 | — | — | EP | claimed |
| WO-2001029029-A1 | TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-04-26 | — | — | WO | claimed |
| EP-1222185-A1 | TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001029029-A1 | TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-04-26 | — | — | WO | disclosed |