Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1004615 | 0.83 | NAMPT (0.55) | MEN1KMT2ATRPM8ALDH1A1HTR2A | |
| SCHEMBL7528191 | 0.81 | HPGD (0.48) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL29173030 | 0.81 | EGFR (0.47) | MEN1KMT2ATRPM8ALDH1A1HTR2A | |
| SCHEMBL1003822 | 0.80 | HTR1A (0.47) | MEN1KMT2ATRPM8ALDH1A1HTR2A | |
| SCHEMBL2592951 | 0.80 | CES2 (0.47) | HPGDLMNAMAPTTP53TSHR | |
| SCHEMBL23791942 | 0.79 | HTR1A (0.46) | MEN1KMT2ATRPM8ALDH1A1HTR2A | |
| SCHEMBL1003732 | 0.79 | ADRA2C (0.49) | MEN1KMT2ATRPM8ALDH1A1HTR2A | |
| SCHEMBL12130667 | 0.77 | MEN1 (0.54) | MEN1KMT2AHTR2AHPGDMLYCD | |
| SCHEMBL14427596 | 0.76 | MEN1 (0.67) | MEN1KMT2AHSD11B1LMNANPSR1 | |
| SCHEMBL8034861 | 0.76 | HTR1A (0.50) | MEN1KMT2ATRPM8HTR2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020147331-A1 | Methods for synthesis of oligonucleotides | ISIS PHARMACEUTICALS, INC. | 2002-10-10 | — | — | US | claimed |
| WO-2002062811-A2 | IMPROVED METHODS FOR SYNTHESIS OF OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 2002-08-15 | — | — | WO | claimed |
| US-20020147331-A1 | Methods for synthesis of oligonucleotides | ISIS PHARMACEUTICALS, INC. | 2002-10-10 | — | — | US | disclosed |
| WO-2002062811-A2 | IMPROVED METHODS FOR SYNTHESIS OF OLIGONUCLEOTIDES | ISIS PHARMACEUTICALS, INC. (US) | 2002-08-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020147331-A1 | Methods for synthesis of oligonucleotides | RNGTT, TYMP, PNP | MEN1 2222/4885KMT2A 3974/4885TRPM8 4043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.