Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.78 |
| ▸ | RAB9A | P51151 | 8/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.78 |
| ▸ | MAPT | P10636 | 4/20 | 0.78 |
| ▸ | GUSB | P08236 | 1/20 | 0.63 |
| ▸ | CA1 | P00915 | 3/20 | 0.62 |
| ▸ | CA2 | P00918 | 3/20 | 0.62 |
| ▸ | CA9 | Q16790 | 2/20 | 0.62 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10245542 | 0.88 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4607599 | 0.85 | RAB9A (0.73) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL7533267 | 0.82 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL17226737 | 0.82 | RAB9A (0.77) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1036939 | 0.81 | TSHR (0.63) | NPC1RAB9AALDH1A1MAPTGAA | |
| SCHEMBL3757160 | 0.81 | RAB9A (0.76) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL656666 | 0.81 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL13589152 | 0.81 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1505273 | 0.81 | MAPT (0.66) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2837185 | 0.79 | RAB9A (0.73) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380187-B2 | FUNGICIDES | YU DINGWEI TIM (US) | 2002-04-30 | — | — | US | disclosed |
| US-20020002193-A1 | Thiadiazole antifungal agents | YU DINGWEI TIM (US) | 2002-01-03 | — | — | US | disclosed |
| US-6281217-B2 | ANTIFUNGAL ACTIVITY AGAINST A VARIETY OF FUNGI INCLUDING STRAINS WHICH HAVE PROVEN TO BE RESISTANT TO TREATMENT WITH KNOWN ANTIFUNGAL AGENTS SUCH AS FLUCONAZOLE. | YU DINGWEI TIM (US) | 2001-08-28 | — | — | US | disclosed |
| US-6277873-B1 | CONTROLLING DRUG RESISTANT FUNGI | YU DINGWEI TIM (US) | 2001-08-21 | — | — | US | disclosed |
| US-20010000512-A1 | Novel class of piperazino substituted thiazoles | YU DINGWEI TIM (US) | 2001-04-26 | — | — | US | disclosed |
| US-20010000177-A1 | Novel class of thiomorpholino substituted thiazoles | YU DINGWEI TIM (US) | 2001-04-05 | — | — | US | disclosed |
| US-20010000178-A1 | PYRIDYL SUBSTITUTED THIAZOLES | YU DINGWEI TIM (US) | 2001-04-05 | — | — | US | disclosed |
| US-6156776-A | Diaryl substituted thiazoles useful in the treatment of fungal infections | YU DINGWEI TIM (US) | 2000-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010000177-A1 | Novel class of thiomorpholino substituted thiazoles | THUMPD1, ERG28, THOC2 | NPC1 1178/4885RAB9A 4242/4885SMN1; SMN2 4644/4885 |
| US-20020002193-A1 | Thiadiazole antifungal agents | ERG28, NAT1, AADAC | NPC1 763/4885RAB9A 3829/4885SMN1; SMN2 4461/4885 |
| US-20010000512-A1 | Novel class of piperazino substituted thiazoles | ERG28, DPM1, NAT1 | NPC1 835/4885RAB9A 3881/4885SMN1; SMN2 4712/4885 |
| US-20010000178-A1 | PYRIDYL SUBSTITUTED THIAZOLES | PDXK, OXA1L, ERG28 | NPC1 1114/4885RAB9A 4224/4885SMN1; SMN2 4264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.