Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.63 |
| ▸ | SDHB | P21912 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | HPGD | P15428 | 4/20 | 0.63 |
| ▸ | STAT3 | P40763 | 2/20 | 0.63 |
| ▸ | STAT1 | P42224 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5593297 | 0.82 | SDHB (0.68) | BPTFNPSR1SDHBKMT2ALMNA | |
| SCHEMBL14194280 | 0.82 | RAB9A (0.48) | BPTFNPSR1SDHBKMT2ALMNA | |
| SCHEMBL5592833 | 0.81 | BPTF (0.63) | BPTFNPSR1SDHBKMT2ALMNA | |
| SCHEMBL5593055 | 0.80 | BPTF (0.61) | BPTFNPSR1SDHBKMT2ALMNA | |
| SCHEMBL5592879 | 0.80 | KMT2A (0.62) | BPTFNPSR1SDHBKMT2ALMNA | |
| SCHEMBL7871659 | 0.80 | SDHB (0.62) | BPTFNPSR1SDHBKMT2ALMNA | |
| SCHEMBL7528348 | 0.79 | LMNA (0.64) | BPTFNPSR1SDHBKMT2ALMNA | |
| SCHEMBL5593019 | 0.78 | BPTF (0.58) | BPTFNPSR1SDHBKMT2ALMNA | |
| SCHEMBL29975914 | 0.78 | NPSR1 (1.00) | BPTFNPSR1SDHBKMT2ALMNA | |
| SCHEMBL5592890 | 0.78 | BPTF (0.58) | BPTFNPSR1SDHBKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1359376-A | Carboxylic acid derivatives compriosing aryl-substituted nitrogen heterocycles, their production and their use as endothel in receptor antagonists | BASF AG (DE) | 2002-07-17 | — | — | CN | disclosed |
| EP-1181281-A2 | NOVEL CARBOXYLIC ACID DERIVATIVES COMPRISING ARYL-SUBSTITUTED NITROGEN HETEROCYCLES, THEIR PRODUCTION AND THEIR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000073276-A2 | CARBOXYLIC ACID DERIVATIVES COMPRISING ARYL-SUBSTITUTED NITROGEN HETEROCYCLES, THEIR PRODUCTION AND THEIR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-07 | — | — | WO | disclosed |