Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.53 |
| ▸ | ATG4B | Q9Y4P1 | 11/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 9/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Octane SCHEMBL27977732 | 1.00 | HCAR2 (0.53) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Maleic Acid SCHEMBL27638142 | 1.00 | HCAR2 (0.53) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Fumaric Acid SCHEMBL384277 | 1.00 | HCAR2 (0.53) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Maleic Acid SCHEMBL27638152 | 1.00 | HCAR2 (0.53) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Maleic Acid SCHEMBL900756 | 1.00 | HCAR2 (0.53) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Fumaric Acid SCHEMBL901027 | 1.00 | HCAR2 (0.53) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Maleic Acid SCHEMBL28649558 | 0.98 | HCAR2 (0.52) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Maleic Acid SCHEMBL1274105 | 0.91 | HCAR2 (0.50) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Maleic Acid SCHEMBL538717 | 0.91 | HCAR2 (0.50) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Maleic Acid SCHEMBL3685225 | 0.91 | HCAR2 (0.50) | HCAR2ATG4BPLA2G1BTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116788137-A | High-stability composite automobile front carpet assembly and production method thereof | 广德天运新技术股份有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-110050051-A | Adhesive composition and use thereof | 东亚合成株式会社 | 2019-07-23 | — | — | CN | disclosed |
| CN-103030892-B | Polypropylene bumper special material and preparation method thereof | SHANGHAI TAOHONG CHEMICAL TECHNOLOGY CO., LTD. (CN) | 2014-10-22 | — | — | CN | disclosed |
| CN-103030892-B | Polypropylene bumper special material and preparation method thereof | SHANGHAI TAOHONG CHEMICAL TECHNOLOGY CO., LTD. (CN) | 2014-10-22 | — | — | CN | disclosed |
| CN-103709562-A | Steam rubber hose | SUZHOU HUADONG RUBBER CO LTD | 2014-04-09 | — | — | CN | disclosed |
| CN-102604222-B | Polypropylene material for automobile interior trimming parts and preparation method thereof | SHANGHAI HAN MOULD SHAPE CO LTD | 2013-08-21 | — | — | CN | disclosed |
| CN-103030892-A | Polypropylene bumper special material and preparation method thereof | SHANGHAI TAOHONG CHEMICAL TECH | 2013-04-10 | — | — | CN | disclosed |
| CN-103030892-A | Polypropylene bumper special material and preparation method thereof | SHANGHAI TAOHONG CHEMICAL TECH | 2013-04-10 | — | — | CN | disclosed |
| CN-102604222-A | Polypropylene material for automobile interior trimming parts and preparation method thereof | SHANGHAI HAN MOULD SHAPE CO LTD | 2012-07-25 | — | — | CN | disclosed |
| US-20020193486-A1 | Chlorinated polyolefin resin composition | SHOWA DENKO K.K. (JP) | 2002-12-19 | — | — | US | disclosed |
| EP-1242536-A2 | CHLORINATED POLYOLEFIN RESIN COMPOSITION | Showa Denko K.K. (JP) | 2002-09-25 | — | — | EP | disclosed |
| WO-2002016487-A2 | CHLORINATED POLYOLEFIN RESIN COMPOSITION | SHOWA DENKO K.K. (JP) | 2002-02-28 | — | — | WO | disclosed |
| CN-1054117-C | Method for producing alkyl acrylate or alkyl methacrylate | QILU PETROCHEMICAL CO CHINESE (CN) | 2000-07-05 | — | — | CN | disclosed |
| CN-1127745-A | Process for producing alkyl acrylate or methacrylate | QILU PETRO CHEM CO CHINA PETRO (CN) | 1996-07-31 | — | — | CN | disclosed |