Fumaric Acid

Fumaric Acid

SCHEMBL901027

CCCCCCCC[Sn]CCCCCCCC.O=C(O)C=CC(=O)O

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol

The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 3/20 0.53
ATG4B Q9Y4P1 11/20 0.45
PLA2G1B P04054 9/20 0.45
THRA P10827 1/20 0.45
THRB P10828 1/20 0.45
CYP1A2 P05177 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
RECQL P46063 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Octane SCHEMBL27977732 1.00 HCAR2 (0.53) HCAR2ATG4BPLA2G1BTHRATHRB
Maleic Acid SCHEMBL27638142 1.00 HCAR2 (0.53) HCAR2ATG4BPLA2G1BTHRATHRB
Fumaric Acid SCHEMBL384277 1.00 HCAR2 (0.53) HCAR2ATG4BPLA2G1BTHRATHRB
Maleic Acid SCHEMBL27638152 1.00 HCAR2 (0.53) HCAR2ATG4BPLA2G1BTHRATHRB
Maleic Acid SCHEMBL900756 1.00 HCAR2 (0.53) HCAR2ATG4BPLA2G1BTHRATHRB
Maleic Acid SCHEMBL7532138 1.00 HCAR2 (0.53) HCAR2ATG4BPLA2G1BTHRATHRB
Maleic Acid SCHEMBL28649558 0.98 HCAR2 (0.52) HCAR2ATG4BPLA2G1BTHRATHRB
Maleic Acid SCHEMBL1274105 0.91 HCAR2 (0.50) HCAR2ATG4BPLA2G1BTHRATHRB
Maleic Acid SCHEMBL538717 0.91 HCAR2 (0.50) HCAR2ATG4BPLA2G1BTHRATHRB
Maleic Acid SCHEMBL3685225 0.91 HCAR2 (0.50) HCAR2ATG4BPLA2G1BTHRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1138 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-121574564-A Liquid silicone rubber for cold-shrink cable accessories and preparation method thereof 东莞市正安有机硅科技有限公司 2026-02-27 CN claimed
EP-4665792-A1 FILLED MOISTURE-CROSSLINKABLE POLYMERIC COMPOSITIONS Dow Global Technologies LLC (US) 2025-12-24 EP claimed
CN-120158034-A PVC/ABS alloy material and preparation method and application thereof 金发科技股份有限公司 2025-06-17 CN claimed
CN-120149341-A Preparation method of positive electrode lead plaster for prolonging cycle life of lead storage battery 天能电池集团股份有限公司 2025-06-13 CN claimed
WO-2024186717-A1 FILLED MOISTURE-CROSSLINKABLE POLYMERIC COMPOSITIONS DOW GLOBAL TECHNOLOGIES LLC (US) 2024-09-12 WO claimed
CN-113969023-B High-content methyl octabromoether flame-retardant master batch and preparation method and application thereof 山东旭锐新材股份有限公司 2024-05-31 CN claimed
CN-117810618-B Corrosion-resistant protective film for lithium battery and preparation method and application thereof 广州鸿图新材料科技有限公司 2024-05-28 CN claimed
CN-117467400-A Silicone adhesive for photovoltaic module frame and preparation method and application thereof 苏州中来光伏新材股份有限公司 2024-01-30 CN claimed
EP-3688082-B1 COMPOSITIONS COMPRISING A TIN-BASED CATALYST AND TITANIUM DIOXIDE FOR MOISTURE CURE OF SILANE-FUNCTIONALIZED ETHYLENIC POLYMERS DOW GLOBAL TECHNOLOGIES LLC (US) 2023-11-08 EP claimed
CN-115028934-B Bright red pearl master batch and preparation method thereof 广州丽盈塑料有限公司 2023-09-05 CN claimed
US-5719255-A HOT MELT ADHESIVE FOR POLYVINYL CHLORIDE HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1998-02-17 US claimed
CN-1035942-C Process for producing higher cyanoacetic ester NITTO CHEMICAL INDUSTRY CO LTD (JP) 1997-09-24 CN claimed
CN-1118162-A Process for producing higher cyanoacetic ester NITTO CHEMICAL INDUSTRY CO LTD (JP) 1996-03-06 CN claimed
EP-0598872-A1 ADDITIVES FOR POLYMER COMPOSITIONS BAXTER INTERNATIONAL INC. (US) 1994-06-01 EP claimed
WO-1993024563-A1 ADDITIVES FOR POLYMER COMPOSITIONS BAXTER INTERNATIONAL INC. (US) 1993-12-09 WO claimed
US-4895761-A STORAGE STABILITY, ORGANOTIN COMPOUND COATED OVER CURED POLYSILOXANE SHIN ETSU CHEMICAL CO., LTD. (JP) 1990-01-23 US claimed
US-4357434-A HYDROXY-MERCAPTAN COMPOUNDS AJINOMOTO COMPANY INCORPORATED (JP) 1982-11-02 US claimed
US-4146674-A FOR PILLOWS BAYER AKTIENGESELLSCHAFT (DE) 1979-03-27 US claimed
US-4052350-A CALCIUM COMPOUND SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA (JA) 1977-10-04 US claimed
US-4041014-A N-OCTYL TIN ISOOCTYL MERCAPTOACETATES AND A DI-N-OCTYL TIN MALEATE OLIGOMER AS DISCOLORATION INHIBITORS M&T CHEMICALS INC. (US) 1977-08-09 US claimed