Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.53 |
| ▸ | ATG4B | Q9Y4P1 | 11/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 9/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Octane SCHEMBL27977732 | 1.00 | HCAR2 (0.53) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Maleic Acid SCHEMBL27638142 | 1.00 | HCAR2 (0.53) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Fumaric Acid SCHEMBL384277 | 1.00 | HCAR2 (0.53) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Maleic Acid SCHEMBL27638152 | 1.00 | HCAR2 (0.53) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Fumaric Acid SCHEMBL901027 | 1.00 | HCAR2 (0.53) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Maleic Acid SCHEMBL7532138 | 1.00 | HCAR2 (0.53) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Maleic Acid SCHEMBL28649558 | 0.98 | HCAR2 (0.52) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Maleic Acid SCHEMBL1274105 | 0.91 | HCAR2 (0.50) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Maleic Acid SCHEMBL538717 | 0.91 | HCAR2 (0.50) | HCAR2ATG4BPLA2G1BTHRATHRB | |
| Maleic Acid SCHEMBL3685225 | 0.91 | HCAR2 (0.50) | HCAR2ATG4BPLA2G1BTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4711411-A1 | FAST-CURING TWO-COMPONENT SILICONE COMPOSITION WITH IMPROVED TEMPERATURE STABILITY | Sika Technology AG (CH) | 2026-03-18 | — | — | EP | disclosed |
| EP-4549514-A1 | MOISTURE-CURABLE RTV SILICONE COMPOSITION OFFERING HIGH TEAR PROPAGATION RESISTANCE AND STORAGE STABILITY | Sika Technology AG (CH) | 2025-05-07 | — | — | EP | disclosed |
| US-12011490-B2 | Dental photocurable composition excellent in operability and storage stability | SHOFU INC. (JP) | 2024-06-18 | — | — | US | disclosed |
| EP-3888616-B1 | DENTAL PHOTOCURABLE COMPOSITION EXCELLENT IN COLOR TONE SELECTIVITY | SHOFU INC (JP) | 2024-05-15 | — | — | EP | disclosed |
| EP-3881818-B1 | DENTAL PHOTOCURABLE COMPOSITIONS COMPRISING PHOTOPOLYMERIZATION INITIATOR COMPRISING AN ARYLIODONIUM SALT | SHOFU KK (JP) | 2024-03-06 | — | — | EP | disclosed |
| EP-4306595-A1 | MOISTURE AND RADICALLY CURABLE SILICONE ACRYLATE COMPOSITION FOR CURED-IN-PLACE GASKETING | Sika Technology AG (CH) | 2024-01-17 | — | — | EP | disclosed |
| US-11779524-B2 | Photopolymerization initiator comprising an aryliodonium salt for dental photocurable compositions | KABUSHIKI KAISHA SHOFU (JP) | 2023-10-10 | — | — | US | disclosed |
| US-11696874-B2 | Dental photocurable composition excellent in color tone selectivity | SHOFU INC. (JP) | 2023-07-11 | — | — | US | disclosed |
| US-11622916-B2 | Photocurable composition excellent in curing depth | SHOFU INC. (JP) | 2023-04-11 | — | — | US | disclosed |
| US-11622917-B2 | Dental photocurable composition containing high soluble photoacid generator | SHOFU INC. (JP) | 2023-04-11 | — | — | US | disclosed |
| EP-2202276-A1 | Silicon compound with accelerated integration | Sika Technology AG (CH) | 2010-06-30 | — | — | EP | disclosed |
| WO-2010057963-A1 | STORAGE-STABLE TWO-COMPONENT SILICONE ADHESIVES AND SEALANTS WITH EXTENDED MIXER OPEN TIME | SIKA TECHNOLOGY AG (CH) | 2010-05-27 | — | — | WO | disclosed |
| EP-2189501-A1 | Storage-stable two-component silicone adhesives and sealants having a prolonged open time in a mixer | Sika Technology AG (CH) | 2010-05-26 | — | — | EP | disclosed |
| US-20100069524-A1 | Single-Component dental composition containing silane coupling agent and acidic group-containing polymerizable monomer | KABUSHIKI KAISHA SHOFU | 2010-03-18 | — | — | US | disclosed |
| US-20090304612-A1 | Artificial nail composition having excellent appearance | KABUSHIKI KAISHA SHOFU (JP) | 2009-12-10 | — | — | US | disclosed |
| US-20090304611-A1 | Artificial nail composition having excellent appearance | KABUSHIKI KAISHA SHOFU (JP) | 2009-12-10 | — | — | US | disclosed |
| EP-1717268-A1 | Process for the preparation of flowable, curable polyorganosiloxane masses containing reinforcing filler | Wacker Chemie AG (DE) | 2006-11-02 | — | — | EP | disclosed |
| EP-0787766-B2 | Ambient vulcanising silicone rubbers crosslinking by condensation mechanism | WACKER CHEMIE GMBH (DE) | 2004-03-17 | — | — | EP | disclosed |
| EP-0787766-B1 | Ambient vulcanising silicone rubbers crosslinking by condensation mechanism | WACKER CHEMIE GMBH (DE) | 1999-08-04 | — | — | EP | disclosed |
| EP-0787766-A1 | Ambient vulcanising silicone rubbers crosslinking by condensation mechanism | Wacker-Chemie GmbH (DE) | 1997-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069524-A1 | Single-Component dental composition containing silane coupling agent and acidic group-containing polymerizable monomer | CAD, ITGA1, CIB1 | HCAR2 674/4885ATG4B 4673/4885PLA2G1B 1925/4885 |
| US-12011490-B2 | Dental photocurable composition excellent in operability and storage stability | H1-0, CCND1, CCNT1 | HCAR2 1455/4885ATG4B 2858/4885PLA2G1B 1848/4885 |
| US-11622917-B2 | Dental photocurable composition containing high soluble photoacid generator | AP2S1, AP3S1, ASIC1 | HCAR2 3584/4885ATG4B 3422/4885PLA2G1B 1272/4885 |
| US-11622916-B2 | Photocurable composition excellent in curing depth | ODC1, AOC2, CCNT1 | HCAR2 658/4885ATG4B 2600/4885PLA2G1B 549/4885 |
| US-11779524-B2 | Photopolymerization initiator comprising an aryliodonium salt for dental photocurable compositions | PHF6, BRD1, BRD7 | HCAR2 4023/4885ATG4B 4144/4885PLA2G1B 2647/4885 |
| US-11696874-B2 | Dental photocurable composition excellent in color tone selectivity | HBG1, MARK1, KATNA1 | HCAR2 1900/4885ATG4B 4290/4885PLA2G1B 2168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.