SCHEMBL753227

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL752312	0.83	HTT (0.34)	HTTALDH1A1GNRHRLMNAMAPT
	SCHEMBL2484464	0.79	HTT (0.37)	HTTALDH1A1GNRHRMAPK1LMNA
	SCHEMBL16921569	0.76	TYMP (0.46)	HTTALDH1A1GNRHRMAPK1LMNA
	SCHEMBL757197	0.74	HTT (0.31)	HTTALDH1A1LMNARAB9APOLB
	SCHEMBL751294	0.72	HDAC1 (0.46)	ALDH1A1MAPTRAB9ASMN1; SMN2KMT2A
	SCHEMBL765052	0.72	KMT2A (0.48)	HTTALDH1A1LMNAMAPTTSHR
	SCHEMBL756355	0.72	LMNA (0.56)	HTTALDH1A1LMNAMAPTKMT2A
	SCHEMBL11941061	0.71	CTSB (0.43)	HTTMAPK1LMNAMAPTTSHR
	SCHEMBL757095	0.69	MTNR1A (0.43)	HTTALDH1A1MAPTSMN1; SMN2KMT2A
	SCHEMBL754516	0.69	FFAR4 (0.42)	HTTALDH1A1LMNAMAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.