Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.41 |
| ▸ | CDC42BPB | Q9Y5S2 | 3/20 | 0.41 |
| ▸ | ATR | Q13535 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7532403 | 1.00 | HTR6 (0.49) | HTR6MAP4K4HRH4MEN1KMT2A | |
| SCHEMBL7532374 | 0.81 | HTR6 (0.48) | HTR6MAP4K4HRH4MEN1KMT2A | |
| SCHEMBL7532372 | 0.81 | HTR6 (0.48) | HTR6MAP4K4HRH4MEN1KMT2A | |
| SCHEMBL27556790 | 0.77 | HTR6 (0.42) | HTR6MAP4K4HRH4ROCK2ROCK1 | |
| SCHEMBL27573339 | 0.77 | HTR6 (0.42) | HTR6MAP4K4HRH4ROCK2ROCK1 | |
| SCHEMBL27573256 | 0.77 | HTR6 (0.42) | HTR6MAP4K4HRH4ROCK2ROCK1 | |
| SCHEMBL21245786 | 0.75 | ALDH1A1 (0.50) | MAP4K4HRH4MEN1KMT2AATR | |
| SCHEMBL21267453 | 0.75 | ALDH1A1 (0.50) | MAP4K4HRH4MEN1KMT2AATR | |
| SCHEMBL10036371 | 0.75 | MAPT (0.55) | HTR6MAP4K4HRH4MEN1KMT2A | |
| SCHEMBL29508926 | 0.75 | ALDH1A1 (0.50) | MAP4K4HRH4MEN1KMT2AATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228066-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001032646-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-10 | — | — | WO | disclosed |