Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 5/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | GOT1 | P17174 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7532665 | 0.85 | DRD2 (0.52) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL7539032 | 0.85 | DRD2 (0.57) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL7532948 | 0.84 | DRD2 (0.66) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL26508415 | 0.80 | HTR2A (0.57) | HTR2AHTR1AHTR7DRD4ABCC1 | |
| SCHEMBL7532686 | 0.78 | DRD2 (0.59) | DRD2HTR2AHTR1AHTR7ABCC1 | |
| SCHEMBL7532701 | 0.78 | HTR1A (0.72) | DRD2HTR1A | |
| SCHEMBL7538925 | 0.77 | DRD2 (0.68) | DRD2HTR1A | |
| SCHEMBL7532842 | 0.76 | HTR6 (0.62) | DRD2HTR2AHTR1AHTR7DRD4 | |
| SCHEMBL7534561 | 0.76 | HTR1A (0.70) | DRD2HTR1AHTR7HTR6KCNH2 | |
| SCHEMBL7535043 | 0.76 | DRD2 (0.60) | DRD2HTR2AHTR1AHTR7DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2002-09-12 | — | — | US | claimed |
| US-6391882-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS | H. LUNDBECK A/S (DK) | 2002-05-21 | — | — | US | claimed |
| CN-1336925-A | 4,5,6 and 7-indole and indoline derivatives, their prepn. and use | LUNDBECK & CO AS H (DK) | 2002-02-20 | — | — | CN | claimed |
| EP-1089997-A1 | 4,5,6 AND 7-INDOLE AND INDOLINE DERIVATIVES, THEIR PREPARATION AND USE | H.Lundbeck A/S (DK) | 2001-04-11 | — | — | EP | claimed |
| WO-1999067237-A1 | 4,5,6 AND 7-INDOLE AND INDOLINE DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 1999-12-29 | — | — | WO | claimed |
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2002-09-12 | — | — | US | disclosed |
| US-6391882-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS | H. LUNDBECK A/S (DK) | 2002-05-21 | — | — | US | disclosed |
| CN-1336925-A | 4,5,6 and 7-indole and indoline derivatives, their prepn. and use | LUNDBECK & CO AS H (DK) | 2002-02-20 | — | — | CN | disclosed |
| EP-1089997-A1 | 4,5,6 AND 7-INDOLE AND INDOLINE DERIVATIVES, THEIR PREPARATION AND USE | H.Lundbeck A/S (DK) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067237-A1 | 4,5,6 AND 7-INDOLE AND INDOLINE DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 1999-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | HTR2C, HTR1A, HTR7 | DRD2 49/4885HTR2A 6/4885HTR1A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.