SCHEMBL7532963

SCHEMBL7532963

O=C(Nc1cccc(Cl)c1)c1sccc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.49
CYP1A2 P05177 2/20 0.49
CYP2D6 P10635 2/20 0.49
CYP2C9 P11712 2/20 0.49
CYP2C19 P33261 2/20 0.49
HTT P42858 2/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
GPR27 Q9NS67 2/20 0.48
AVPR2 P30518 1/20 0.48
LMNA P02545 3/20 0.48
HPGD P15428 2/20 0.48
TSHR P16473 1/20 0.48
CCR9 P51686 4/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
P2RX1 P51575 1/20 0.45
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
ACLY P53396 1/20 0.44
RAF1 P04049 1/20 0.44
LCK P06239 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7534436 0.88 LMNA (0.60) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL7534376 0.86 L3MBTL1 (0.52) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL7532549 0.85 KAT6A (0.50) CYP3A4HTTGPR27AVPR2LMNA
SCHEMBL7533623 0.85 ACLY (0.55) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL7533934 0.84 HTT (0.52) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL7533627 0.84 P2RX1 (0.45) HTTLMNAHPGDTSHRSMN1; SMN2
SCHEMBL7531711 0.83 CYP1A2 (0.52) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL7538051 0.83 HTT (0.49) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL7533632 0.83 HTT (0.46) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL7534822 0.83 HTT (0.51) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002028353-A2 PHOSPHATE TRANSPORT INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2002-04-11 WO claimed
WO-2002028353-A2 PHOSPHATE TRANSPORT INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2002-04-11 WO disclosed