Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871601 | 0.79 | HTR1A (0.64) | HTR7SLC6A4ADRA1D | |
| SCHEMBL7203954 | 0.79 | HRH4 (0.53) | CHRNA7HTR7ADRA1BHRH3HRH4 | |
| SCHEMBL7214623 | 0.79 | HTR7 (0.50) | CHRNA7HTR7ADRA1BHRH3SLC6A2 | |
| SCHEMBL8872131 | 0.78 | HTR1A (0.59) | HTR7SLC6A4ADRA1D | |
| SCHEMBL7219760 | 0.78 | SIGMAR1 (0.49) | CHRNA7HTR7ADRA1BHRH3ADRA1D | |
| SCHEMBL73543 | 0.76 | AOC3 (0.47) | CHRNA7SLC6A4 | |
| SCHEMBL7533221 | 0.75 | HTR2B (0.60) | CHRNA7 | |
| SCHEMBL8871261 | 0.73 | HTR1A (0.55) | HTR7SLC6A4 | |
| SCHEMBL12993141 | 0.73 | CYP2A6 (0.44) | CHRNA7HTR7ADRA1BHRH3SLC6A4 | |
| SCHEMBL3640169 | 0.73 | AOC3 (0.44) | HTR7ADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222185-A1 | TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2002-07-17 | — | — | EP | claimed |
| WO-2001029029-A1 | TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-04-26 | — | — | WO | claimed |
| EP-1222185-A1 | TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001029029-A1 | TETRAHYDROBENZINDOLONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-04-26 | — | — | WO | disclosed |