Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MMP1 | P03956 | 5/20 | 0.58 |
| ▸ | MMP13 | P45452 | 2/20 | 0.58 |
| ▸ | MMP9 | P14780 | 2/20 | 0.58 |
| ▸ | MMP3 | P08254 | 6/20 | 0.56 |
| ▸ | MMP7 | P09237 | 4/20 | 0.56 |
| ▸ | MMP8 | P22894 | 4/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533195 | 1.00 | ALDH1A1 (0.64) | ALDH1A1HTTLMNASMN1; SMN2MMP1 | |
| SCHEMBL7534267 | 0.90 | ALDH1A1 (0.62) | ALDH1A1HTTLMNASMN1; SMN2MMP1 | |
| SCHEMBL7534274 | 0.90 | ALDH1A1 (0.62) | ALDH1A1HTTLMNASMN1; SMN2MMP1 | |
| SCHEMBL7531694 | 0.88 | MMP1 (0.73) | LMNAMMP1MMP13MMP9MMP3 | |
| SCHEMBL7531686 | 0.88 | MMP1 (0.73) | LMNAMMP1MMP13MMP9MMP3 | |
| SCHEMBL2977278 | 0.87 | ALDH1A1 (0.72) | ALDH1A1HTTLMNASMN1; SMN2MMP9 | |
| SCHEMBL1385016 | 0.87 | ALDH1A1 (0.72) | ALDH1A1HTTLMNASMN1; SMN2MMP9 | |
| SCHEMBL7568599 | 0.87 | MMP1 (0.75) | LMNAMMP1MMP13MMP9MMP3 | |
| SCHEMBL7568594 | 0.87 | MMP1 (0.75) | LMNAMMP1MMP13MMP9MMP3 | |
| SCHEMBL3717923 | 0.85 | MMP1 (0.73) | ALDH1A1HTTLMNASMN1; SMN2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-H1992-H1 | INHIBITION OF METALLOPROTEINASES AND TUMOR NECROSIS FACTOR CONVERTASE WHICH DEGRADE PROTEIN COMPONENTS OF EXTRACELLULAR MATRIX | AGOURON PHARMACEUTICALS, INC. | 2001-09-04 | — | — | US | disclosed |
| WO-1998050348-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-12 | — | — | WO | disclosed |