Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7561995 | 0.86 | MMP1 (0.49) | MMP1ADAM17NPC1MEN1KMT2A | |
| SCHEMBL7563529 | 0.82 | CTSL (0.52) | MMP1ADAM17NPC1MEN1KMT2A | |
| SCHEMBL7560380 | 0.81 | CTSK (0.49) | MMP1ADAM17NPC1MEN1KMT2A | |
| SCHEMBL7524135 | 0.80 | MMP1 (0.47) | MMP1ADAM17MEN1KMT2ACTSK | |
| SCHEMBL7673959 | 0.80 | MMP1 (0.45) | MMP1ADAM17NPC1MEN1KMT2A | |
| SCHEMBL7532726 | 0.79 | CTSK (0.55) | MMP1ADAM17NPC1MEN1KMT2A | |
| SCHEMBL8659988 | 0.79 | PARP1 (0.55) | MMP1ADAM17NPC1MEN1KMT2A | |
| SCHEMBL8659986 | 0.79 | PARP1 (0.55) | MMP1ADAM17NPC1MEN1KMT2A | |
| SCHEMBL7561086 | 0.78 | CTSK (0.44) | MMP1ADAM17NPC1MEN1KMT2A | |
| SCHEMBL4062161 | 0.76 | PARP1 (0.62) | NPC1MEN1KMT2ARAB9AEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983228-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-0983228-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998050342-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | disclosed |