SCHEMBL7533339

SCHEMBL7533339

O=C(Cc1ccc(O)cc1)c1ccccc1O

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.69
ESR1 P03372 1/20 0.68
SHBG P04278 1/20 0.68
ESR2 Q92731 1/20 0.68
LMNA P02545 3/20 0.56
NPC1 O15118 3/20 0.56
RAB9A P51151 3/20 0.56
SMN1; SMN2 Q16637 3/20 0.56
HTT P42858 2/20 0.56
GAA P10253 1/20 0.56
MAPT P10636 1/20 0.56
ALOX12 P18054 1/20 0.56
ALOX5 P09917 1/20 0.55
FNTA P49354 1/20 0.55
FNTB P49356 1/20 0.55
LIG1 P18858 1/20 0.53
ALDH1A1 P00352 2/20 0.51
HPGD P15428 2/20 0.51
MEN1 O00255 1/20 0.51
CYP3A4 P08684 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29586388 0.88 HPGD (0.56) CYP19A1ESR1SHBGESR2LMNA
SCHEMBL8376 0.88 HPGD (0.56) CYP19A1ESR1SHBGESR2LMNA
SCHEMBL17263407 0.85 GAA (0.66) CYP19A1ESR1SHBGESR2LMNA
SCHEMBL3346345 0.85 ESR1 (0.64) CYP19A1ESR1SHBGESR2LMNA
SCHEMBL17561051 0.85 CYP19A1 (0.51) CYP19A1ESR1SHBGESR2LMNA
Phloroglucinol SCHEMBL28077693 0.85 LMNA (0.55) CYP19A1ESR1SHBGESR2LMNA
SCHEMBL1841587 0.81 CYP19A1 (1.00) CYP19A1ESR1SHBGESR2LMNA
SCHEMBL312243 0.81 ESR1 (1.00) ESR1SHBGESR2LMNANPC1
SCHEMBL30503014 0.81 ESR1 (1.00) ESR1SHBGESR2LMNANPC1
SCHEMBL16324510 0.81 ESR1 (0.73) ESR1SHBGESR2LMNANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0615448-B1 SEX STEROID ACTIVITY INHIBITORS ENDORECH INC (CA) 2002-05-02 EP disclosed
US-5840735-A ESTROGEN ENDORECHERCHE INC. (CA) 1998-11-24 US disclosed
US-5686465-A PROVIDE ANTIESTROGENIC EFFECTS; USEFUL IN TREATMENT OF BREAST CANCER ENDORECHERCHE INC. (CA) 1997-11-11 US disclosed
US-5395842-A Inhibitors of sex steroids ENDORECHERCHE INC. (CA) 1995-03-07 US disclosed
EP-0615448-A1 SEX STEROID ACTIVITY INHIBITORS ENDORECHERCHE INC. (CA) 1994-09-21 EP disclosed
WO-1993010741-A2 SEX STEROID ACTIVITY INHIBITORS ENDORECHERCHE INC. (CA) 1993-06-10 WO disclosed