SCHEMBL8376

SCHEMBL8376

O=C(Cc1ccccc1)c1ccccc1O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 4/20 0.56
KDM4E B2RXH2 3/20 0.56
ALDH1A1 P00352 3/20 0.56
GAA P10253 1/20 0.56
MAPK1 P28482 1/20 0.56
CA12 O43570 1/20 0.56
CA1 P00915 1/20 0.56
CA2 P00918 1/20 0.56
HMGB1 P09429 1/20 0.56
CA4 P22748 1/20 0.56
CA6 P23280 1/20 0.56
CA7 P43166 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
CA9 Q16790 1/20 0.56
NAPRT Q6XQN6 1/20 0.56
CA14 Q9ULX7 1/20 0.56
TSHR P16473 3/20 0.55
TDP1 Q9NUW8 1/20 0.55
CYP19A1 P11511 1/20 0.53
CES2 O00748 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29586388 1.00 HPGD (0.56) HPGDKDM4EALDH1A1GAAMAPK1
Phloroglucinol SCHEMBL28077693 0.93 LMNA (0.55) HPGDKDM4EALDH1A1GAAMAPK1
SCHEMBL7533339 0.88 CYP19A1 (0.69) HPGDKDM4EALDH1A1GAACA12
SCHEMBL7129795 0.87 MEN1 (0.62) ALDH1A1MAPK1CES2CES1AKR1B1
SCHEMBL1882002 0.86 PIK3CA (0.59) HPGDKDM4EALDH1A1GAAMAPK1
SCHEMBL17561051 0.85 CYP19A1 (0.51) HPGDKDM4EALDH1A1GAAMAPK1
SCHEMBL17263407 0.85 GAA (0.66) HPGDKDM4EALDH1A1GAAMAPK1
SCHEMBL5034195 0.84 LMNA (0.58) HPGDKDM4EALDH1A1GAAMAPK1
SCHEMBL20901402 0.83 ALOX5 (0.55) HPGDKDM4EALDH1A1GAAMAPK1
SCHEMBL146018 0.81 ESR1 (0.80) HPGDKDM4EALDH1A1GAAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 436 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3383200-B1 COMPOSITIONS SYMRISE AG (DE) 2019-11-06 EP claimed
EP-2386211-B1 USE OF RUBUSOSIDE TO REDUCE OR SUPPRESS PARTICULAR UNPLEASANT TASTE SENSATIONS SYMRISE AG (DE) 2016-08-10 EP claimed
CN-104018293-B A kind of fire-retardant car roof fabric 宁波高新区夏远科技有限公司 2016-07-20 CN claimed
CN-104018293-A Flame-retardant vehicle ceiling fabric NINGBO XIAYUAN TECHNOLOGY CO LTD 2014-09-03 CN claimed
WO-2014121341-A1 ADHESIVE AND METHOD OF MANUFACTURING SAME BOWER AERO PTY LTD (AU) 2014-08-14 WO claimed
EP-2340719-B1 Aroma composition comprising o-coumaric acid to reduce or suppress undesirable taste impressions of sweeteners SYMRISE AG (DE) 2014-02-19 EP claimed
JP-4726484-B2 2011-07-20 JP claimed
EP-2340719-A1 Aroma composition comprising o-coumaric acid to reduce or suppress undesirable taste impressions of sweeteners Symrise AG (DE) 2011-07-06 EP claimed
US-20110158919-A1 AROMA COMPOSITION COMPRISING O-COUMARIC ACID TO REDUCE OR SUPPRESS UNDESIRABLE TASTE IMPRESSIONS OF SWEETENERS SYMRISE AG (DE) 2011-06-30 US claimed
EP-2008530-B1 Aroma composition for reducing or suppressing unwanted bitter and astringent impressions SYMRISE AG (DE) 2011-01-19 EP claimed
US-20050256321-A1 Manufacture of isoflavones DSM IP ASSETS B.V. (NL) 2005-11-17 US claimed
CN-1684950-A Preparation of isoflavones DSM IP ASSETS BV (NL) 2005-10-19 CN claimed
EP-1523478-A2 MANUFACTURE OF ISOFLAVONES DSM IP Assets B.V. (NL) 2005-04-20 EP claimed
EP-1032568-B1 PROCESS FOR THE PREPARATION OF ISOFLAVONES UNIV MICHIGAN STATE (US) 2005-01-26 EP claimed
CN-1544430-A Isoflavone compound preparing method 浙江大学 2004-11-10 CN claimed
WO-2004009576-A2 MANUFACTURE OF ISOFLAVONES DSM IP ASSETS B.V. (NL) 2004-01-29 WO claimed
EP-1032568-A4 PROCESS FOR THE PREPARATION OF ISOFLAVONES UNIV MICHIGAN STATE (US) 2003-03-05 EP claimed
EP-1032568-A1 PROCESS FOR THE PREPARATION OF ISOFLAVONES MICHIGAN STATE UNIVERSITY (US) 2000-09-06 EP claimed
WO-2000015627-A1 PROCESS FOR THE PREPARATION OF ISOFLAVONES MICHIGAN STATE UNIVERSITY (US) 2000-03-23 WO claimed
US-5981775-A FROM A 2'-HYDROXYDEOXYBENZOIN USING PREPARED N,N'-DIMETHYL(CHLOROMETHYLENE)AMMONIUM CHLORIDE AS A REACTANT IN BORONTRIFLUORIDE ETHERATE OR OTHER LEWIS ACID AS A SOLVENT BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) 1999-11-09 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050256321-A1 Manufacture of isoflavones HAAO, HAO2, CYP2F1 HPGD 71/4885KDM4E 2160/4885ALDH1A1 1856/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.