Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Phloroglucinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | SHBG | P04278 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376 | 0.93 | HPGD (0.56) | LMNAESR1SHBGESR2TDP1 | |
| SCHEMBL29586388 | 0.93 | HPGD (0.56) | LMNAESR1SHBGESR2TDP1 | |
| SCHEMBL5034195 | 0.88 | LMNA (0.58) | LMNAESR1SHBGESR2TDP1 | |
| SCHEMBL7533339 | 0.85 | CYP19A1 (0.69) | LMNAESR1SHBGESR2TDP1 | |
| SCHEMBL20901402 | 0.84 | ALOX5 (0.55) | LMNAESR1SHBGESR2TDP1 | |
| SCHEMBL17263402 | 0.83 | PTGS2 (0.50) | LMNAESR1SHBGESR2TDP1 | |
| SCHEMBL146018 | 0.82 | ESR1 (0.80) | LMNAESR1SHBGESR2GAA | |
| SCHEMBL30497946 | 0.82 | ESR1 (0.80) | LMNAESR1SHBGESR2GAA | |
| SCHEMBL9061935 | 0.82 | ESR1 (0.59) | LMNAESR1SHBGESR2GAA | |
| SCHEMBL7129795 | 0.80 | MEN1 (0.62) | LMNAMAPK1MAPTALDH1A1FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104018293-B | A kind of fire-retardant car roof fabric | 宁波高新区夏远科技有限公司 | 2016-07-20 | — | — | CN | disclosed |