Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533622 | 0.79 | GPR84 (0.42) | IDO1GPR84HTR2ATAAR1 | |
| SCHEMBL7258599 | 0.76 | IDO1 (0.63) | IDO1GPR84HTR2ARET | |
| SCHEMBL7410008 | 0.73 | IDO1 (0.61) | IDO1GPR84HTR2ARETHRH1 | |
| SCHEMBL7425981 | 0.71 | KMT2A (0.47) | IDO1HTR2ATAAR1KMT2A | |
| SCHEMBL9244789 | 0.69 | IDO1 (0.59) | IDO1GPR84HTR2ARETHRH1 | |
| SCHEMBL7425987 | 0.68 | SMPD1 (0.47) | IDO1 | |
| SCHEMBL11658615 | 0.67 | IDO1 (0.56) | IDO1GPR84MEN1KMT2A | |
| SCHEMBL448659 | 0.67 | IDO1 (0.59) | IDO1GPR84HTR2ARET | |
| SCHEMBL14461584 | 0.67 | IDO1 (0.59) | IDO1GPR84 | |
| SCHEMBL9038190 | 0.67 | L3MBTL1 (0.53) | HRH1TAAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874819-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997023457-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1997-07-03 | — | — | WO | disclosed |