SCHEMBL7534007

SCHEMBL7534007

CN(C(CSCc1ccccn1)C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 8/20 0.54
MMP9 P14780 7/20 0.54
MMP1 P03956 6/20 0.54
ADAM17 P78536 3/20 0.54
DUT P33316 1/20 0.46
MMP2 P08253 5/20 0.44
MMP3 P08254 3/20 0.44
ALDH1A1 P00352 1/20 0.43
HPGD P15428 1/20 0.43
ALOX15 P16050 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
HSD17B10 Q99714 1/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
ADAMTS5 Q9UNA0 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
MMP8 P22894 1/20 0.40
MMP14 P50281 1/20 0.40
MMP16 P51512 1/20 0.40
PGR P06401 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7534005 1.00 MMP13 (0.54) MMP13MMP9MMP1ADAM17DUT
SCHEMBL7536309 0.91 MMP13 (0.54) MMP13MMP9MMP1ADAM17DUT
SCHEMBL7536302 0.91 MMP13 (0.54) MMP13MMP9MMP1ADAM17DUT
SCHEMBL7539814 0.83 MMP1 (0.46) MMP13MMP9MMP1ADAM17DUT
SCHEMBL7539821 0.83 MMP1 (0.46) MMP13MMP9MMP1ADAM17DUT
SCHEMBL7532363 0.83 MMP13 (0.51) MMP13MMP9MMP1ADAM17DUT
SCHEMBL7533839 0.83 BMP1 (0.49) MMP13MMP9MMP1ADAM17DUT
SCHEMBL7533835 0.83 BMP1 (0.49) MMP13MMP9MMP1ADAM17DUT
SCHEMBL7532360 0.83 MMP13 (0.51) MMP13MMP9MMP1ADAM17DUT
SCHEMBL7532310 0.80 MMP13 (0.64) MMP13MMP9MMP1ADAM17DUT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998050348-A1 METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES AGOURON PHARMACEUTICALS, INC. (US) 1998-11-12 WO claimed
US-H1992-H1 INHIBITION OF METALLOPROTEINASES AND TUMOR NECROSIS FACTOR CONVERTASE WHICH DEGRADE PROTEIN COMPONENTS OF EXTRACELLULAR MATRIX AGOURON PHARMACEUTICALS, INC. 2001-09-04 US disclosed
WO-1998050348-A1 METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES AGOURON PHARMACEUTICALS, INC. (US) 1998-11-12 WO disclosed