Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 11/20 | 0.54 |
| ▸ | MMP9 | P14780 | 10/20 | 0.54 |
| ▸ | MMP1 | P03956 | 7/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.54 |
| ▸ | MMP2 | P08253 | 7/20 | 0.46 |
| ▸ | MMP3 | P08254 | 4/20 | 0.46 |
| ▸ | DUT | P33316 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | MMP16 | P51512 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | BMP1 | P13497 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7536309 | 1.00 | MMP13 (0.54) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7534005 | 0.91 | MMP13 (0.54) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7534007 | 0.91 | MMP13 (0.54) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7534131 | 0.84 | MMP13 (0.57) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7534128 | 0.84 | MMP13 (0.57) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7533849 | 0.83 | MMP1 (0.46) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7533847 | 0.83 | MMP1 (0.46) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7540502 | 0.83 | MMP13 (0.51) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7540496 | 0.83 | MMP13 (0.51) | MMP13MMP9MMP1ADAM17MMP2 | |
| SCHEMBL7538443 | 0.83 | BMP1 (0.49) | MMP13MMP9MMP1ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-H1992-H1 | INHIBITION OF METALLOPROTEINASES AND TUMOR NECROSIS FACTOR CONVERTASE WHICH DEGRADE PROTEIN COMPONENTS OF EXTRACELLULAR MATRIX | AGOURON PHARMACEUTICALS, INC. | 2001-09-04 | — | — | US | claimed |
| WO-1998050348-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-12 | — | — | WO | claimed |
| US-H1992-H1 | INHIBITION OF METALLOPROTEINASES AND TUMOR NECROSIS FACTOR CONVERTASE WHICH DEGRADE PROTEIN COMPONENTS OF EXTRACELLULAR MATRIX | AGOURON PHARMACEUTICALS, INC. | 2001-09-04 | — | — | US | disclosed |
| WO-1998050348-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-12 | — | — | WO | disclosed |