Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7537152 | 0.83 | DHODH (0.40) | DHODHALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL7533976 | 0.81 | PARP1 (0.33) | DHODHALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL7483421 | 0.80 | DHODH (0.43) | DHODHMAPTKDM5BTRPV4CYP1A2 | |
| SCHEMBL7488250 | 0.80 | PTGS1 (0.45) | POLBDHODHALDH1A1HSD17B10KDM4E | |
| SCHEMBL7484570 | 0.78 | GAA (0.35) | DHODHMAPTKDM5BGAA | |
| SCHEMBL7537246 | 0.77 | DHODH (0.41) | DHODHMAPTKDM5BRAB9ANPSR1 | |
| SCHEMBL7534112 | 0.75 | OPRM1 (0.50) | POLBALDH1A1HSD17B10KDM4EALPL | |
| SCHEMBL6767179 | 0.67 | POLB (0.35) | POLBDHODHALDH1A1HSD17B10KDM4E | |
| SCHEMBL6164575 | 0.65 | CCNA2 (0.38) | ALDH1A1HSD17B10KDM4EALPLHPGD | |
| SCHEMBL6770073 | 0.65 | MAPT (0.34) | DHODHALDH1A1MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |