Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7484570 | 0.87 | GAA (0.35) | DHODHSRCPTGS2PTGS1MAPT | |
| SCHEMBL7537246 | 0.87 | DHODH (0.41) | DHODHSRCCA1CA2RAB9A | |
| SCHEMBL7483421 | 0.86 | DHODH (0.43) | DHODHMAPTPIK3CDPIK3R2PIK3CA | |
| SCHEMBL7488250 | 0.83 | PTGS1 (0.45) | DHODHALDH1A1PTGS1MEN1KMT2A | |
| SCHEMBL7534115 | 0.83 | POLB (0.36) | DHODHALDH1A1MEN1KMT2AHTT | |
| SCHEMBL7533976 | 0.74 | PARP1 (0.33) | DHODHALDH1A1MEN1KMT2AHTT | |
| SCHEMBL7537151 | 0.73 | OPRM1 (0.54) | SRCALDH1A1MEN1KMT2AHTT | |
| SCHEMBL6772430 | 0.68 | CCNA2 (0.44) | DHODHSRCALDH1A1MEN1KMT2A | |
| SCHEMBL5214539 | 0.67 | KMT2A (0.49) | DHODHSRCCA1CA2ALDH1A1 | |
| SCHEMBL6770531 | 0.65 | MEN1 (0.40) | DHODHSRCALDH1A1PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |