Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 3/20 | 0.40 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7537152 | 0.87 | DHODH (0.40) | DHODHSRCNPBWR1MCHR1LMNA | |
| SCHEMBL7484570 | 0.79 | GAA (0.35) | DHODHSRCNPBWR1MCHR1KDM5B | |
| SCHEMBL7488250 | 0.79 | PTGS1 (0.45) | DHODHMAPTTSHRNPSR1 | |
| SCHEMBL7483421 | 0.78 | DHODH (0.43) | DHODHKDM5BMAPT | |
| SCHEMBL7537240 | 0.78 | OPRM1 (0.58) | DHODHSRCMAPTCA1CA2 | |
| SCHEMBL7534115 | 0.77 | POLB (0.36) | DHODHKDM5BMAPTRAB9ANPSR1 | |
| SCHEMBL6772794 | 0.73 | CCNA2 (0.40) | DHODHSRCDGAT2NPBWR1MCHR1 | |
| SCHEMBL6777360 | 0.71 | OPRM1 (0.39) | DHODHSRCDGAT2NPBWR1MCHR1 | |
| SCHEMBL7533976 | 0.69 | PARP1 (0.33) | DHODHLMNAMAPTTSHRNPSR1 | |
| SCHEMBL6166539 | 0.69 | SRC (0.39) | DHODHSRCMAPTRAB9ASLC16A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |