SCHEMBL7535627

SCHEMBL7535627

Cc1cccc2[nH]c(C(=O)N[C@H](C(=O)NC(CC(=O)O)C(=O)CBr)C(C)C)c(CC(C)C)c12

nearest known ligand 0.40

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CASP3 P42574 19/20 0.40
CASP8 Q14790 15/20 0.40
CASP1 P29466 7/20 0.40
CASP7 P55210 7/20 0.40
CASP6 P55212 5/20 0.36
MMP2 P08253 1/20 0.34
MMP9 P14780 1/20 0.34
MMP8 P22894 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8606968 0.91 CASP3 (0.41) CASP3CASP8CASP1CASP7CASP6
SCHEMBL7536650 0.90 MMP2 (0.38) MMP2MMP9MMP8
SCHEMBL7535127 0.85 CASP3 (0.47) CASP3CASP8CASP1CASP7CASP6
SCHEMBL7540320 0.84 CASP3 (0.49) CASP3CASP8CASP6
SCHEMBL7538962 0.83 CASP3 (0.58) CASP3CASP8CASP7CASP6
SCHEMBL8608833 0.80 CASP3 (0.44) CASP3CASP8CASP1CASP7CASP6
SCHEMBL5970017 0.79 CASP3 (0.42) CASP3CASP8CASP1CASP7CASP6
SCHEMBL7536449 0.76 MMP2 (0.36) CASP3CASP8CASP1CASP6MMP2
SCHEMBL7543444 0.74 CASP3 (0.49) CASP3CASP8CASP7CASP6
SCHEMBL7201731 0.72 CASP3 (0.43) CASP3CASP8CASP1CASP7CASP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1159291-A1 C-TERMINAL MODIFIED (N-SUBSTITUTED)-2-INDOLYLCARBONYLDIPEPTIDES AS INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES Idun Pharmaceuticals, Inc. (US) 2001-12-05 EP disclosed
WO-2001000658-A1 C-TERMINAL MODIFIED (N-SUBSTITUTED)-2-INDOLYLCARBONYLDIPEPTIDES AS INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES IDUN PHARMACEUTICALS, INC. (US) 2001-01-04 WO disclosed