Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2424191 | 0.74 | PAX8 (0.35) | JAK1SMN1; SMN2 | |
| SCHEMBL29078006 | 0.70 | SMN1; SMN2 (0.56) | MEN1KMT2AMAPTSMN1; SMN2TRPM8 | |
| SCHEMBL29017156 | 0.69 | GPR119 (0.38) | GPR119MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL28885178 | 0.68 | SMN1; SMN2 (0.41) | MEN1KMT2AMAPTSMN1; SMN2TRPM8 | |
| SCHEMBL27564741 | 0.68 | SMN1; SMN2 (0.38) | USP30GPR119MEN1KMT2AMAPT | |
| SCHEMBL27879537 | 0.67 | KMT2A (0.50) | GPR119MEN1KMT2ASMN1; SMN2TRPM8 | |
| SCHEMBL5313021 | 0.67 | ROCK2 (0.36) | JAK1JAK2 | |
| SCHEMBL26250446 | 0.67 | S1PR1 (0.35) | GPR119MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL14845093 | 0.66 | ALDH1A1 (0.35) | MAPTSMN1; SMN2TRPM8 | |
| SCHEMBL20025198 | 0.66 | SMN1; SMN2 (0.48) | MEN1KMT2AMAPTSMN1; SMN2TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430014-A1 | ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132601-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2010-11-18 | — | — | WO | disclosed |